{
  "abstract": "Inherited fibrinogen disorders (IFDs) are rare, and limited evidence-based management guidelines exist, especially regarding haematological malignancies and haematopoietic stem cell transplantion (HSCT). This case highlights the successful multidisciplinary management of an adult patient with acute Philadelphia-negative B-cell lymphoblastic leukaemia (B-ALL) and IFD from induction through HSCT. A patient in his 20s with an IFD is diagnosed with B-ALL and receives induction chemotherapy, including dose-reduced pegaspargase (PEG-Asp), blinatumomab consolidative therapy and HSCT for post-induction measurable residual disease (MRD) positivity. Management involved prophylactic anticoagulation (AC) during induction and pharmacokinetic-guided fibrinogen replacement. Complications were iatrogenic intracranial hypotension and acute catheter-associated proximal deep vein thrombosis managed with therapeutic AC. One year post-HSCT, he remained MRD-negative with 100% donor chimerism. This case highlights a management strategy for patients with IFD requiring chemotherapy and/or HSCT and addresses a critical gap in knowledge.",
  "authors": [
    {
      "affiliations": [
        "Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"
      ],
      "name": "Yiseiry Perez-Melendez"
    },
    {
      "affiliations": [
        "Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"
      ],
      "name": "Tharakeswari Selvakumar"
    },
    {
      "affiliations": [
        "Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"
      ],
      "name": "Charles Greenberg"
    },
    {
      "affiliations": [
        "Pediatrics, Medical University of South Carolina, Charleston, South Carolina, USA"
      ],
      "name": "Shayla Bergman"
    },
    {
      "affiliations": [
        "Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"
      ],
      "name": "Alexander Coltoff"
    },
    {
      "affiliations": [
        "Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"
      ],
      "name": "Kimberley Youkhana"
    }
  ],
  "title": "Management of inherited fibrinogen disorder during chemotherapy and allogeneic stem cell transplant",
  "uid": "ccf9cb4b-3258-56ec-b150-fc5f271989c0"
}