{
  "abstract": "Undifferentiated pleomorphic sarcoma (UPS) is an aggressive mesenchymal malignancy with a poor prognosis in unresectable head and neck cases. A woman in her late 70s presented with unresectable maxillary UPS (cT4bN0M0, Stage IVB) involving the skull base and showing membranous epidermal growth factor receptor (EGFR) expression in 10%–20% of tumour cells. After a partial response to definitive chemoradiotherapy, she underwent two sessions of Alluminox photoimmunotherapy with Akalux (cetuximab–sarotalocan sodium) activated by near-infrared illumination via transoral and transnasal optical diffusers under intraoperative navigation and cone-beam CT. This technique enables selective tumour ablation, induces immunogenic cell death and offers potential synergy with immune checkpoint inhibitors. She achieved complete radiological and pathological remission with minimal toxicity and remains disease-free with preserved oral function at 8 months.",
  "authors": [
    {
      "affiliations": [
        "Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo, Shimane Prefecture, Japan"
      ],
      "name": "Takahiro Kanno"
    },
    {
      "affiliations": [
        "Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo, Shimane Prefecture, Japan"
      ],
      "name": "Masako Fujioka-Kobayashi"
    },
    {
      "affiliations": [
        "Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Izumo, Shimane Prefecture, Japan",
        "Department of Medical Oncology, Shimane University Hospital, Izumo, Shimane, Japan"
      ],
      "name": "Hiroto Tatsumi"
    },
    {
      "affiliations": [
        "Department of Otorhinolaryngology-Head and Neck Surgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan"
      ],
      "name": "Noriaki Aoi"
    },
    {
      "affiliations": [
        "Department of Otorhinolaryngology-Head and Neck Surgery, Shimane University Faculty of Medicine, Izumo, Shimane, Japan"
      ],
      "name": "Tatsunori Sakamoto"
    }
  ],
  "title": "Complete response of unresectable maxillary undifferentiated pleomorphic sarcoma with Alluminox photoimmunotherapy",
  "uid": "5619b09b-4459-5284-a806-8231c7c4cc69"
}