{
  "abstract": "A male in his 50s presented with profound leucocytosis, systemic symptoms and marked hepatosplenomegaly. Initial workup with peripheral blood flow cytometry suggested T-cell prolymphocytic leukaemia as the most likely diagnosis. However, bone marrow biopsy with comprehensive immunogenetic testing ultimately identified anaplastic lymphoma kinase-positive anaplastic large cell lymphoma in its leukemic phase. The treatment course was with targeted agents with less immunosuppressive risk, after taking into consideration that he was a Jehovah’s Witness, who would not be able to receive blood products. Despite a transient response, the disease progressed rapidly. This case underscores the importance of a broad differential diagnosis, judicious use of advanced diagnostics and individualised treatment planning, particularly in rare and aggressive lymphoproliferative disorders.",
  "authors": [
    {
      "affiliations": [
        "Internal Medicine, Cleveland Clinic, Cleveland, Ohio, USA"
      ],
      "name": "Debolina Pramanik"
    },
    {
      "affiliations": [
        "Internal Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG - Minas Gerais, Brazil"
      ],
      "name": "Bernardo Henrique Mendes Correa"
    },
    {
      "affiliations": [
        "Princess Alia Governmental Hospital, Hebron, Palestine"
      ],
      "name": "Amal Akram Abo Jheasha"
    },
    {
      "affiliations": [
        "Hematology/Oncology, Cleveland Clinic, Cleveland, Ohio, USA"
      ],
      "name": "Chana Peysin"
    }
  ],
  "title": "Diagnostic and treatment challenges associated with the atypical presentation of ALK-positive anaplastic large cell lymphoma in a Jehovah’s Witness patient",
  "uid": "f14b0f39-454b-5a92-ae86-8aa001fa0aeb"
}