{
  "abstract": "Pneumocystis jirovecii pneumonia (PJP) is a life-threatening opportunistic infection in immunocompromised patients. While classically seen in HIV/AIDS, it is increasingly recognised in those receiving lymphodepleting chemotherapy and radiation. Early identification and treatment are critical. A man in his 60s with glioblastoma multiforme on adjuvant temozolomide and cranial radiation presented with a 10-day history of progressive dyspnoea. Home pulse oximetry fell to 70% on room air. CT chest showed bilateral ground-glass opacities. Induced sputum PCR was positive for P. jirovecii; HIV serology was negative. He was started on high-dose intravenous trimethoprim–sulfamethoxazole and a prednisone taper, with de-escalation of broad-spectrum antibiotics. By hospital day 7, he remained on high-flow nasal cannula at 25 L/min fraction of inspired oxygen (FiO₂) 60%, maintaining a peripheral capillary oxygen saturation (SpO₂) ≥92%. He was speaking in full sentences and ambulating without desaturation. This case highlights the need for vigilance for PJP in solid-tumour patients receiving temozolomide and radiation, and the importance of early diagnosis and therapy.",
  "authors": [
    {
      "affiliations": [
        "School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"
      ],
      "name": "Carson Price Cooper"
    },
    {
      "affiliations": [
        "Osmania Medical College, Hyderabad, Telangana, India"
      ],
      "name": "Lakshmi Sharath Chandran Thurikepally"
    },
    {
      "affiliations": [
        "School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"
      ],
      "name": "Prescott Remington"
    },
    {
      "affiliations": [
        "Tribhuvan University Institute of Medicine, Maharajganj, Lumbini Province, Nepal"
      ],
      "name": "Manthan Sanjay Shinde"
    },
    {
      "affiliations": [
        "School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA"
      ],
      "name": "Chankokporn Puchongmart"
    }
  ],
  "title": "Pneumocystis jirovecii pneumonia in a chemotherapy-induced immunocompromised patient with glioblastoma multiforme",
  "uid": "535a566e-0c87-5799-a70b-c01abc0ecfea"
}