{
  "abstract": "A woman in her early 70s was admitted with a 2-day history of dizziness, vomiting and a sensation of abnormal eye movements. Her medical history included rectal cancer and a benign solitary fibrous tumour of the spine. Although she had undergone several surgical resections, progressive regrowth of the spinal tumour eventually caused permanent lower-limb paralysis. On admission, her temperature was 36.7°C, blood pressure was 161/83 mm Hg and pulse rate was 55 beats per minute. She was alert and oriented. Neurological examination revealed chaotic, multidirectional saccadic eye movements consistent with opsoclonus, along with subtle myoclonus of the neck ( online supplemental video 1 and 2). Other cranial nerve examinations were normal, with no ocular motility disturbance. As a sequela of her spinal tumour, no voluntary movement was observed in the lower limbs, with preserved strength in the upper limbs. Sensation was diminished in the lower limbs, whereas it was intact in the upper limbs. Finger-to-nose testing could not be reliably performed with the patient’s eyes open. Impaired pronation–supination movements were observed bilaterally, but truncal or lower limb ataxia could not be assessed due to complete paralysis of the lower limbs. Over the next few days, she developed impaired consciousness, bilateral upper limb weakness and involuntary movements of the limbs.",
  "authors": [
    {
      "affiliations": [
        "General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka Prefecture, Japan"
      ],
      "name": "Shogo Shirota"
    },
    {
      "affiliations": [
        "General Medicine, Osaka Medical and Pharmaceutical University Hospital, Takatsuki, Osaka Prefecture, Japan"
      ],
      "name": "Tomio Suzuki"
    }
  ],
  "title": "Opsoclonus–myoclonus syndrome with anti-SOX1 antibodies",
  "uid": "9b1a30b2-8ed4-5284-908f-ae83e9edb63a"
}