{
  "abstract": "Rosai-Dorfman-Destombes disease (RDD) is a rare, benign histiocytic disorder, most often involving lymph nodes but showing extranodal manifestations in nearly 50% of cases, particularly in the skin and upper respiratory tract. A hallmark histological feature is emperipolesis—large CD68+ and S100+ histiocytes containing intact inflammatory cells. We report a unique case of bilateral testicular RDD in a man with prior extranodal marginal zone lymphoma of the lungs. Three years after lymphoma remission, he presented with bilateral testicular enlargement. Ultrasound and positron emission tomography/CT showed diffuse hypoechoic parenchyma with metabolic activity suggestive of malignancy. Bilateral orchiectomy revealed tan-yellow, fleshy masses infiltrating the testicular parenchyma. Histology confirmed RDD with emperipolesis and S100+/CD68+/CD1a− phenotype. Testicular RDD is extremely uncommon, with only ~15 cases described to date, and its association with haematological malignancy remains poorly understood. Recognition of this entity is essential to avoid unnecessary oncological treatment.",
  "authors": [
    {
      "affiliations": [
        "Universidad Peruana Cayetano Heredia, Lima, Peru"
      ],
      "name": "Efrain Lee-Diaz"
    },
    {
      "affiliations": [
        "Pathology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, USA"
      ],
      "name": "Victoria Claire Vaughan"
    },
    {
      "affiliations": [
        "Pathology, UCHealth Highlands Ranch Hospital, Highlands Ranch, Colorado, USA"
      ],
      "name": "Lian Zhang"
    },
    {
      "affiliations": [
        "Pathology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, USA"
      ],
      "name": "Zenggang Pan"
    },
    {
      "affiliations": [
        "Pathology, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, USA"
      ],
      "name": "Francisco G La Rosa"
    }
  ],
  "title": "Rosai-Dorfman disease mimicking testicular malignancy in a patient with marginal zone lymphoma of the lung",
  "uid": "cc635740-8121-5f47-9fbb-09fff913cf28"
}