{
  "abstract": "Vincristine, a widely used chemotherapeutic agent, may rarely cause optic neuropathy leading to acute vision loss. We describe a patient with T cell lymphoblastic lymphoma who developed sudden bilateral visual impairment following the third cycle of vincristine-based chemotherapy. Extensive evaluation excluded alternative causes, including central nervous system infiltration, opportunistic infections and metabolic disturbances. A diagnosis of vincristine-induced optic neuropathy was made. The patient received high-dose intravenous methylprednisolone along with pyridoxine supplementation, resulting in marked visual recovery within days. This case highlights a potentially reversible but under-recognised complication of vincristine therapy. Early recognition and timely intervention are crucial to prevent permanent visual disability.",
  "authors": [
    {
      "affiliations": [
        "Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"
      ],
      "name": "Akash Paruthi"
    },
    {
      "affiliations": [
        "Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"
      ],
      "name": "Swati Srivastava"
    },
    {
      "affiliations": [
        "Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"
      ],
      "name": "Sunil Kumar Mahavar"
    },
    {
      "affiliations": [
        "Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"
      ],
      "name": "Rajendra Kumar Kasana"
    },
    {
      "affiliations": [
        "Department of General Medicine, Sawai Man Singh Medical College and Hospital, Jaipur, India"
      ],
      "name": "Naveen Verma"
    }
  ],
  "title": "Acute vision loss associated with vincristine therapy in T cell lymphoma",
  "uid": "a1550d0f-0446-5edb-8dd8-268b1e9fe537"
}