{
  "abstract": "Neonatal hypocalcaemia (NH) is a common metabolic disorder, particularly in preterm and high-risk infants. It may be life-threatening, with a broad spectrum of clinical manifestations, although early-onset cases can remain clinically silent.We describe a premature infant with refractory early-onset NH, secondary to severe maternal vitamin D deficiency. Despite an initial asymptomatic presentation, the infant developed persistent biochemical abnormalities requiring supplementation with calcium, magnesium and high-dose vitamin D. Maternal evaluation confirmed marked vitamin D deficiency with secondary hyperparathyroidism, highlighting the direct impact of maternal status on neonatal calcium homeostasis.This case illustrates how neonatal vitamin D levels depend almost entirely on maternal stores during pregnancy, making maternal hypovitaminosis D a key and preventable risk factor for NH. It also emphasises the underestimated prevalence of vitamin D deficiency among pregnant women worldwide, especially in vulnerable populations. Early recognition and intervention are therefore essential to prevent complications in both mother and child.",
  "authors": [
    {
      "affiliations": [
        "Children’s Department, Hospital de Cascais Dr José de Almeida, Alcabideche, Lisbon, Portugal"
      ],
      "name": "Madalena Ferreira"
    },
    {
      "affiliations": [
        "Children’s Department, Hospital de Cascais Dr José de Almeida, Alcabideche, Lisbon, Portugal"
      ],
      "name": "Maria Limbert"
    },
    {
      "affiliations": [
        "Children’s Department, Hospital de Cascais Dr José de Almeida, Alcabideche, Lisbon, Portugal"
      ],
      "name": "Sofia Deuchande"
    },
    {
      "affiliations": [
        "Children’s Department, Hospital de Cascais Dr José de Almeida, Alcabideche, Lisbon, Portugal"
      ],
      "name": "Cristina Novais"
    }
  ],
  "title": "Neonatal hypocalcaemia due to maternal vitamin D deficiency: a preventable and underestimated condition",
  "uid": "ca1d5b53-a1e0-5832-9feb-d555130b80e6"
}