{
  "abstract": "Membranous nephropathy (MN) is an important cause of nephrotic syndrome and is associated with significant adverse health outcomes including progression to end-stage kidney disease, complications relating to volume overload and increased risk of venous thromboembolism. Primary MN is frequently linked to antibodies against the phospholipase A2 receptor, although a broader range of target autoantigens are emerging. We report a case of a man in his mid-60s who had been recently diagnosed with antisynthetase syndrome presenting with nephrotic syndrome. A kidney biopsy revealed findings in keeping with MN, including positive immunohistochemical staining for the neural epidermal growth factor-like 1 protein (NELL-1) autoantigen. This report highlights a possible novel association between antisynthetase syndrome and NELL-1 positive MN.",
  "authors": [
    {
      "affiliations": [
        "Renal Medicine Department, East and North Hertfordshire Teaching NHS Trust, Stevenage, England, UK",
        "Clinical and Professional Practice Unit, UCL Medical School, London, England, UK"
      ],
      "name": "Antony P Zacharias"
    },
    {
      "affiliations": [
        "Renal Medicine Department, East and North Hertfordshire Teaching NHS Trust, Stevenage, England, UK"
      ],
      "name": "Md Ariful Hoque"
    },
    {
      "affiliations": [
        "Nephrology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK"
      ],
      "name": "Oscar Swift"
    },
    {
      "affiliations": [
        "Renal Medicine Department, East and North Hertfordshire Teaching NHS Trust, Stevenage, England, UK"
      ],
      "name": "Suresh Mathavakkannan"
    }
  ],
  "title": "NELL-1 positive membranous nephropathy in association with antisynthetase syndrome",
  "uid": "52728263-78de-595c-b35d-77f88496273c"
}