{
  "abstract": "Patients with ankylosing spondylitis (AS) may require biological therapy, particularly tumour necrosis factor (TNF) inhibitors, which are effective but increase the risk of tuberculosis (TB). Secukinumab, an interleukin-17A inhibitor, has not been linked to TB reactivation; however, its safety in the setting of active TB remains unclear. We report two patients with AS who developed active TB during long-term anti-TNF treatment. Both experienced disease flares while receiving anti-TB therapy and needed alternative biologic treatment. Secukinumab was started 2 months after initiating standard four-drug TB therapy and achieved rapid and sustained control of AS activity without compromising TB management. Both patients completed 9 months of anti-TB treatment without adverse events or TB reactivation during 1 year follow-up. These observations suggest that secukinumab may be a safe and effective therapeutic option for patients with AS with concomitant active TB when anti-TNF agents are contraindicated, though confirmation in larger studies is warranted.",
  "authors": [
    {
      "affiliations": [
        "Department of Rheumatology, Gaziantep University, Gaziantep, Turkey"
      ],
      "name": "Fatih Albayrak"
    },
    {
      "affiliations": [
        "Department of Radiology, Sanko University, Gaziantep, Turkey"
      ],
      "name": "Nurcihan Y Savaş"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Hacettepe University, Ankara, Turkey"
      ],
      "name": "Melis Mutlu"
    },
    {
      "affiliations": [
        "Department of Endocrinology and Metabolism, Sanko University, Gaziantep, Turkey"
      ],
      "name": "Zeynel A Sayiner"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Sanko University, Gaziantep, Turkey"
      ],
      "name": "Bunyamin Kisacik"
    }
  ],
  "title": "Treatment experience with secukinumab in two patients with ankylosing spondylitis and concomitant active tuberculosis",
  "uid": "3f95c2c8-5027-5f0a-baea-cea44271be9f"
}