{
  "abstract": "This case report describes two patients with congenital heart disease (CHD) who underwent Fontan palliation surgery in their youth and subsequently developed Fontan-associated liver disease (FALD) in adulthood. While undergoing routine screening for hepatocellular carcinoma (HCC), both patients had significantly elevated serum alpha-fetoprotein testing and diagnostic radiographic findings consistent with early-stage HCC. At the same academic medical centre, both patients were treated with localised yttrium-90 (Y90) radioembolisation therapy, and neither underwent liver transplantation (LT). After Y90 radioembolisation, both patients achieved HCC remission that has sustained at 3 years post-treatment. These cases suggest that Y90 radioembolisation may offer effective, transplant-free management of HCC in selected FALD patients. Given the growing adult FALD population, further studies are needed to guide surveillance and identify predictors of response to non-surgical therapies.",
  "authors": [
    {
      "affiliations": [
        "Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"
      ],
      "name": "Rachel Orbuch"
    },
    {
      "affiliations": [
        "Department of Medicine, Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"
      ],
      "name": "Daniel Ganger"
    },
    {
      "affiliations": [
        "Department of Radiology (Abdominal Imaging) and Surgery (Organ Transplant), Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"
      ],
      "name": "Amir Borhani"
    },
    {
      "affiliations": [
        "Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, Illinois, USA"
      ],
      "name": "Robert J Lewandowski"
    },
    {
      "affiliations": [
        "Department of Medicine, Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA"
      ],
      "name": "Dempsey Hughes"
    }
  ],
  "title": "Treatment of hepatocellular carcinoma in patients with Fontan-associated liver disease with radioembolisation therapy",
  "uid": "1c928432-1c2e-5124-8550-c519998705e6"
}