{
  "abstract": "VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic) is a recently recognised, adult-onset autoinflammatory condition caused by somatic UBA1 mutations, predominantly affecting older men. This condition often mimics autoimmune or infectious diseases, presenting with systemic inflammation and haematologic abnormalities. We describe a man in his 70s with seropositive rheumatoid arthritis who presented with a tender neck mass, recurrent fevers and elevated inflammatory markers. Symptoms improved with corticosteroids but relapsed on tapering. A bone marrow biopsy to investigate persistent inflammation revealed subtle cytoplasmic vacuolation in myeloid precursors, prompting targeted genetic testing that confirmed a somatic UBA1 mutation. This case underscores the diagnostic complexity of VEXAS and the therapeutic challenges of managing this recently recognised entity.",
  "authors": [
    {
      "affiliations": [
        "Department of Medicine, Redland Hospital, Cleveland, Queensland, Australia",
        "School of Medicine, Griffith University Faculty of Health, Gold Coast, Queensland, Australia"
      ],
      "name": "Stanley Du Preez"
    },
    {
      "affiliations": [
        "Department of Immunology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia"
      ],
      "name": "Daniel Schuster"
    },
    {
      "affiliations": [
        "Department of Medicine, Redland Hospital, Cleveland, Queensland, Australia",
        "Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia"
      ],
      "name": "Katrina Chakradeo"
    }
  ],
  "title": "VEXAS syndrome in a patient with seropositive rheumatoid arthritis: lessons in diagnostic vigilance",
  "uid": "c561509a-10e9-58b2-9566-80ae41326965"
}