{
  "abstract": "Systemic capillary leak syndrome (SCLS), also known as Clarkson syndrome, is a rare disease with potential fatal outcome. The clinical picture involves leakage of fluid and protein from the bloodstream into peripheral tissues, resulting in hypoalbuminaemia, elevated haematocrit, oedema and hypotension. The spectrum of the symptoms ranges from discrete swelling/oedema of extremities to fulminant cardiogenic shock. We present a case with a 52-year-old man diagnosed with SCLS after being resuscitated from cardiac arrest, which was complicated by compartment syndrome. The severe episode of capillary leak was potentially triggered by influenza virus infection. With the benefit of hindsight, he presented with symptoms of SCLS 2 years prior the major acute episode. Here we describe this case and review some aspects of the literature on SCLS, with particular focus on the pathogenesis, treatment/prophylaxis and long-term physical and psychological complications.",
  "authors": [
    {
      "affiliations": [
        "Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark"
      ],
      "name": "Lotte Ebdrup"
    },
    {
      "affiliations": [
        "Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA"
      ],
      "name": "Kirk Druey"
    },
    {
      "affiliations": [
        "Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark",
        "Department of Biomedicine, Aarhus University, Aarhus, Denmark",
        "Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"
      ],
      "name": "Trine Hyrup Mogensen"
    }
  ],
  "title": "Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection",
  "uid": "a34834a9-603f-5240-ba41-60083984371a"
}