{
  "abstract": "Diffuse large B cell lymphoma (DLBCL) is a prevalent subtype of non-Hodgkins lymphoma and can occasionally present as a rare and aggressive testicular variant. This case presents a middle-aged male patient with stage IE testicular DLBCL who was successfully treated with DA-EPOCH-R chemotherapy and radiation, attaining a 5 year remission. He later developed neurological symptoms initially attributed to an acoustic neuroma but was ultimately diagnosed with isolated central nervous system (CNS) relapse of DLBCL. CNS recurrence remains a concern, despite prophylactic strategies. The patient was then treated with the MATRix regimen with close monitoring for transplant requirements. This case underscores the question of necessitating CNS prophylaxis in high-risk patients. We also highlight novel therapeutic strategies, and emerging molecular markers may hold promise in improving risk stratification and improving long-term outcomes for this patient population.",
  "authors": [
    {
      "affiliations": [
        "Internal Medicine, LSU Health Shreveport, Shreveport, Louisiana, USA"
      ],
      "name": "Priyanka Anvekar"
    },
    {
      "affiliations": [
        "Internal Medicine, LSU Health Shreveport, Shreveport, Louisiana, USA"
      ],
      "name": "Sheikh Abdullah"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA"
      ],
      "name": "Anil Ananthaneni"
    },
    {
      "affiliations": [
        "Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA"
      ],
      "name": "Poornima Ramadas"
    }
  ],
  "title": "Atypical CNS relapse in early-stage double-hit DLBCL: clinical implications for surveillance and prophylaxis",
  "uid": "228e2bb5-a010-5321-9721-d29b6b5737ac"
}