{
  "abstract": "This case report illustrates a rare case of progressive familial intrahepatic cholestasis type 3. Pruritus was the predominant symptom that led to the diagnosis of this condition in an otherwise healthy adolescent. The onset of symptoms can happen at any age, and the diagnosis may be delayed due to a lack of severe symptoms. Genetic testing confirms the diagnosis. Therapy with ursodeoxycholic acid is recommended, and other anti-pruritic medications can be adjuvant. Disease progression should be monitored.",
  "authors": [
    {
      "affiliations": [
        "Department of Paediatrics, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal"
      ],
      "name": "Catarina Nunes"
    },
    {
      "affiliations": [
        "Department of Paediatrics, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal"
      ],
      "name": "Luísa Ribeiro"
    },
    {
      "affiliations": [
        "Department of Paediatrics, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal"
      ],
      "name": "Maria Torre"
    },
    {
      "affiliations": [
        "Hospital Dona Estefânia, Lisbon, Lisbon, Portugal",
        "Unidade de Transplantação Hepática - PA, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal"
      ],
      "name": "Cristina Gonçalves"
    }
  ],
  "title": "Comprehensive overview of progressive familial intrahepatic cholestasis type 3 and the importance of pruritus as a diagnostic clue",
  "uid": "4241bafd-c00d-5abb-a58c-acc0a5d7f7c8"
}