{
  "abstract": "Non-functioning pancreatic neuroendocrine tumours (pNETs) are frequently diagnosed at advanced stages, thus limiting the feasibility of curative surgery. The potential utility of different therapeutic modalities with neoadjuvant proposals aimed at facilitating curative surgery has been discussed in the literature and international guidelines. Nevertheless, clinical trials are warranted to analyse the role and efficacy of various treatment protocols in this context. The heterogeneity inherent in different pNETs should be acknowledged, as it may influence treatment response. We report a case of an unresectable pNET with metastatic disease, which exhibited a partial response to neoadjuvant chemotherapy, enabling an R0 resection.",
  "authors": [
    {
      "affiliations": [
        "Department of Endocrinology, Diabetes and Metabolism, Hospital Curry Cabral, Unidade Local de Saúde São José, Lisboa, Portugal"
      ],
      "name": "Maria Salomé Serranito"
    },
    {
      "affiliations": [
        "Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal"
      ],
      "name": "Leandro Augusto Silva"
    },
    {
      "affiliations": [
        "Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal"
      ],
      "name": "Andreia Martins Fernandes"
    },
    {
      "affiliations": [
        "Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal"
      ],
      "name": "Ana Rita Elvas"
    },
    {
      "affiliations": [
        "Unidade Local de Saúde da Região de Aveiro, EPE, Aveiro, Portugal"
      ],
      "name": "Isabel Domingues"
    },
    {
      "affiliations": [
        "Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal"
      ],
      "name": "Rui Martins"
    },
    {
      "affiliations": [
        "Instituto Português de Oncologia de Coimbra Francisco Gentil, EPE, Coimbra, Portugal",
        "Faculty of Medicine, University of Porto, Porto, Portugal"
      ],
      "name": "Raquel Martins"
    }
  ],
  "title": "Advanced pancreatic neuroendocrine tumour: the success of ‘neoadjuvant’ chemotherapy",
  "uid": "1fde7412-dd24-51b2-93b1-cdfd21e7b3e0"
}