{
  "abstract": "Hypocalcaemia is a common metabolic abnormality in neonates, with distinct causes based on the timing of onset. Early-onset hypocalcaemia (within 72 hours of life) is typically related to transitional physiology, prematurity, perinatal asphyxia or maternal diabetes. In contrast, late-onset hypocalcaemia (after 72 hours) is less common and may result from high phosphate intake, cow’s milk-based formulas, vitamin D deficiency or resistance, maternal vitamin D deficiency, hypoparathyroidism (eg, DiGeorge syndrome), magnesium deficiency or activating mutations in the calcium-sensing receptor. Clinical manifestations of late-onset hypocalcaemia can include seizures, tetany, irritability, arrhythmias or stridor. While most cases respond to oral calcium, vitamin D and magnesium supplementation, some are refractory to conventional therapy. We report a case of refractory neonatal hypocalcaemia that showed significant improvement with teriparatide, a recombinant parathyroid hormone analogue, highlighting the potential role of advanced pharmacological agents in difficult-to-treat cases of neonatal hypocalcaemia.",
  "authors": [
    {
      "affiliations": [
        "Department of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"
      ],
      "name": "Arohi Gupta"
    },
    {
      "affiliations": [
        "Department of Pediatric Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"
      ],
      "name": "Preeti Dabadghao"
    },
    {
      "affiliations": [
        "Department of Pediatric Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"
      ],
      "name": "Amruta Sathe"
    },
    {
      "affiliations": [
        "Department of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"
      ],
      "name": "Anita Singh"
    },
    {
      "affiliations": [
        "Department of Neonatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"
      ],
      "name": "Kirti Naranje"
    }
  ],
  "title": "Recalcitrant hypocalcaemia responding to teriparatide therapy: a clinical insight",
  "uid": "7fc033a0-b9b1-5a77-b7d6-9444886311e8"
}