{
  "abstract": "Fetal liver calcifications (FLCs) are relatively common findings on prenatal imaging, typically appearing as punctate, hyperechogenic areas with posterior acoustic shadowing. Although they may suggest genetic, infectious or vascular anomalies, isolated cases are often clinically insignificant. We are reporting a case of a pregnant woman in her late 30s whose routine second-trimester ultrasound revealed isolated, coarse FLCs. Despite their ultrasonographic appearance, prenatal investigations—including karyotyping, infection screening and cystic fibrosis testing—were unremarkable. The pregnancy progressed normally, culminating in the term delivery of a healthy male infant. Postnatal imaging confirmed isolated intrahepatic calcifications with no identifiable aetiology. Early vascular events during development were hypothesised. Prenatal diagnosis of FLCs requires consideration of multiple aetiologies and, consequently, targeted investigation. Once potential causes are excluded, isolated FLCs, even when coarse, do not appear to impact fetal or neonatal outcomes. The literature regarding the characterisation and management of coarse FLCs remains limited.",
  "authors": [
    {
      "affiliations": [
        "Departamento da Mulher e da Medicina Reprodutiva, Centro Materno Infantil do Norte Albino Aroso, Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo António, Porto, Portugal"
      ],
      "name": "Carolina Gomes-Pires"
    },
    {
      "affiliations": [
        "Departamento da Mulher e da Medicina Reprodutiva, Centro Materno Infantil do Norte Albino Aroso, Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo António, Porto, Portugal",
        "Centro de Medicina Fetal, Medicina Fetal Porto, Centro Materno Infantil do Norte Albino Aroso, Porto, Portugal"
      ],
      "name": "Ana Cunha"
    },
    {
      "affiliations": [
        "Departamento da Mulher e da Medicina Reprodutiva, Centro Materno Infantil do Norte Albino Aroso, Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo António, Porto, Portugal",
        "Centro de Medicina Fetal, Medicina Fetal Porto, Centro Materno Infantil do Norte Albino Aroso, Porto, Portugal",
        "Unidade de Investigação e Formação, Centro Materno Infantil do Norte Albino Aroso, Porto, Portugal",
        "Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal",
        "Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal"
      ],
      "name": "Luís Guedes-Martins"
    }
  ],
  "title": "Coarse fetal liver calcifications on prenatal imaging: a diagnostic dilemma with uncertain implications",
  "uid": "4ae4a38b-ca29-553d-bfdf-bcff16f32297"
}