{
  "abstract": "Primary urethral adenocarcinoma in females is extremely rare, comprising less than 1% of female genitourinary cancers. Due to its rarity, treatment guidelines are unclear, and most cases present at advanced stages with a poor prognosis. Our case demonstrates the potential for urethra-sparing surgery as an effective treatment option in selected patients. A woman in her late 60s presented with a 2 cm urethral mass and haematuria. MRI revealed a lesion extending toward the vaginal introitus without invasion. She underwent wide local excision, and histopathology confirmed moderately differentiated urethral adenocarcinoma with immunohistochemical positivity for CDX-2, E-cadherin and cytokeratins 7 and 20. Given the complete resection, age and comorbidities, a multidisciplinary team recommended surveillance instead of radical surgery. At 12 months postoperatively, the patient remains recurrence-free and asymptomatic. Our case demonstrates that urethra-sparing surgery is a viable option in select patients. Individualised treatment approaches should be taken that balance oncological control with quality-of-life preservation.",
  "authors": [
    {
      "affiliations": [
        "Urology, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK"
      ],
      "name": "Dayan Jacob"
    },
    {
      "affiliations": [
        "Urology, Darlington Memorial Hospital, Darlington, UK"
      ],
      "name": "Ramachandran Amitharaj"
    },
    {
      "affiliations": [
        "Histopathology, County Durham and Darlington NHS Foundation Trust, Darlington, UK"
      ],
      "name": "Kanchan Trichal"
    },
    {
      "affiliations": [
        "Urology, Darlington Memorial Hospital, Darlington, UK"
      ],
      "name": "Tom O’Hare"
    }
  ],
  "title": "Urethral-sparing surgical management of primary urethral adenocarcinoma in a female patient with successful oncological outcome",
  "uid": "ff0476f6-5704-5480-9eda-29536c5aa320"
}