{
  "abstract": "Conducting a systematic literature review before initiating a new clinical trial can prevent research waste and provide critical justification and valuable insights for designing the trial. Clinical researchers, however, typically lack the resources and experience to conduct systematic reviews. This paper introduces the REVEAL (prior evidence for new trials) guidance—a rigorously developed, user friendly, step-by-step guide for clinical researchers to rapidly, efficiently, and systematically review the literature when planning a trial. REVEAL consists of a detailed guidance document to navigate the process, a structured report form to document the search and findings, and a worked example for practical orientation.",
  "authors": [
    {
      "affiliations": [
        "Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems, 3500 Krems an der Donau, Austria"
      ],
      "name": "Ursula Griebler"
    },
    {
      "affiliations": [
        "Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems, 3500 Krems an der Donau, Austria"
      ],
      "name": "Dominic Ledinger"
    },
    {
      "affiliations": [
        "Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems, 3500 Krems an der Donau, Austria"
      ],
      "name": "Irma Klerings"
    },
    {
      "affiliations": [
        "CLEAR Methods Centre, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland",
        "School of Public Health, University College Cork, Cork, Ireland",
        "MTA-PTE Lendület “Momentum” Evidence in Medicine Research Group, Medical School, University of Pécs, Pécs, Hungary"
      ],
      "name": "Stefan Schandelmaier"
    },
    {
      "affiliations": [
        "Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems, 3500 Krems an der Donau, Austria"
      ],
      "name": "Andreea Dobrescu"
    },
    {
      "affiliations": [
        "Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium"
      ],
      "name": "Mieke Deschodt"
    },
    {
      "affiliations": [
        "CLEAR Methods Centre, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland",
        "Institute of History and Ethics in Medicine, Department of Preclinical Medicine, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany"
      ],
      "name": "Stuart McLennan"
    },
    {
      "affiliations": [
        "Department of Clinical Research, University of Bern, Bern, Switzerland",
        "Research Centre for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland",
        "Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA"
      ],
      "name": "Lars G Hemkens"
    },
    {
      "affiliations": [
        "Department for Evidence-based Medicine and Evaluation, University for Continuing Education Krems, 3500 Krems an der Donau, Austria"
      ],
      "name": "Barbara Nussbaumer-Streit"
    },
    {
      "affiliations": [
        "CLEAR Methods Centre, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland"
      ],
      "name": "Matthias Briel"
    }
  ],
  "title": "Identifying prior evidence for new trials (REVEAL): guidance for clinical researchers",
  "uid": "3440022d-4a85-5823-814e-511d620227f0"
}