{
  "abstract": "While the number of fatal acute SARS-CoV-2 infections has declined since 2020, the proportion of these infections that result in persisting symptoms has not reduced significantly. 1 The continuity or development of new symptoms longer than 3 months after an acute SARS-CoV-2 infection is clinically defined as long covid.2 PEM, a hallmark and debilitating feature, is recognised as one of the most frequent manifestations of long covid and is present in ~80% of patients with the condition.3 PEM is a delayed exacerbation (or new onset) of symptoms after physical or cognitive activity above a patient- and time-dependent threshold, which may persist for days, weeks or months or even result in a permanent change in a patient’s baseline.2 The need to screen for PEM in suspected long covid before initiating a rehabilitation strategy has already been recognised by major health authorities, including the WHO, who heavily cautioned against graded exercise therapies for patients experiencing PEM.2",
  "authors": [
    {
      "affiliations": [
        "Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"
      ],
      "name": "Braeden T Charlton"
    },
    {
      "affiliations": [
        "DeSportarts, Sports and Exercise Medicine Clinic, Utrecht, The Netherlands"
      ],
      "name": "Kasper Janssen"
    },
    {
      "affiliations": [
        "Department of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA"
      ],
      "name": "David M Systrom"
    },
    {
      "affiliations": [
        "Cohen Center for Recovery from Complex Chronic Illness, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "David Putrino"
    },
    {
      "affiliations": [
        "Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"
      ],
      "name": "Rob CI Wüst"
    }
  ],
  "title": "Post-exertional malaise and the myth of cardiac deconditioning: rethinking the pathophysiology of long covid",
  "uid": "6a0c9c44-b27a-5933-82f8-c64300564dbd"
}