{
  "abstract": "Objective To assess the relationship between pincer morphology and incident radiographic hip osteoarthritis (RHOA) and study-specific subgroups.Methods Hips completely free of RHOA at baseline and with follow-up within 4–8 years were drawn from the World COACH consortium. The lateral centre edge angle (LCEA) was calculated uniformly on all baseline radiographs. Moderate pincer morphology was defined as an LCEA ≥40°, and severe pincer morphology as an LCEA ≥45° in sensitivity analyses. The primary outcome was incident RHOA defined by a harmonised OA score. A logistic regression model with generalised mixed effects with three levels (within-cohort, within-person and within-hip side correlation) adjusted for age, biological sex and body mass index (BMI) was employed. Descriptive statistics are reported for age, biological sex and BMI.Results 18 935 hips from nine cohorts were included. 4894 hips (25.8%) had moderate pincer morphology. Within 8 years (mean 6.0±1.7 years), 352 hips (1.9%) developed RHOA. Moderate pincer morphology was not associated with RHOA (OR 1.15 (0.92–1.51)), whereas severe pincer morphology was significantly associated (OR 1.50 95% CI 1.05 to 2.15). Moderate pincer morphology in groups aged 40–50 (RR 2.67, 95% CI 1.43 to 4.95) and BMI ≥25 (RR 1.23 95% CI 0.98 to 1.71) had a higher risk compared with non-pincer hips. Women (RR 1.20 95% CI 0.93 to 1.56) with pincer morphology may be more at risk than men (RR 0.95 95% CI 0.57 to 1.58).Conclusion The odds of developing RHOA within 8 years for hips with severe pincer morphology are 1.5 times higher than pincer-free hips, whereas moderate pincer morphology was not significantly associated with RHOA. Further research is necessary to uncover high risk subgroups of pincer morphology.",
  "authors": [
    {
      "affiliations": [
        "Orthopedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"
      ],
      "name": "Noortje Riedstra"
    },
    {
      "affiliations": [
        "Orthopedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"
      ],
      "name": "Fleur Boel"
    },
    {
      "affiliations": [
        "Orthopedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"
      ],
      "name": "Michiel MA van Buuren"
    },
    {
      "affiliations": [
        "University of Tasmania Menzies Institute for Medical Research, Hobart, Tasmania, Australia"
      ],
      "name": "Harbeer Ahedi"
    },
    {
      "affiliations": [
        "University Medical Centre Utrecht, Utrecht, The Netherlands"
      ],
      "name": "Vahid Arbabi"
    },
    {
      "affiliations": [
        "NDORMS, University of Oxford, Oxford, UK"
      ],
      "name": "Nigel K Arden"
    },
    {
      "affiliations": [
        "Department of Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands"
      ],
      "name": "Sara J Baart"
    },
    {
      "affiliations": [
        "Department of General Practice, Erasmus University Medical Centre, Rotterdam, The Netherlands"
      ],
      "name": "Sita M A Bierma-Zeinstra"
    },
    {
      "affiliations": [
        "Monash University, Melbourne, Victoria, Australia"
      ],
      "name": "Flavia Cicutini"
    },
    {
      "affiliations": [
        "Manchester University, North Manchester, Indiana, USA"
      ],
      "name": "Timothy Cootes"
    },
    {
      "affiliations": [
        "La Trobe University—Bundoora Campus, Bundoora, Victoria, Australia"
      ],
      "name": "Kay M Crossley"
    },
    {
      "affiliations": [
        "Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA"
      ],
      "name": "David T Felson"
    },
    {
      "affiliations": [
        "University Medical Centre Utrecht, Utrecht, The Netherlands"
      ],
      "name": "Willem-Paul Gielis"
    },
    {
      "affiliations": [
        "La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, Australia"
      ],
      "name": "Joshua J Heerey"
    },
    {
      "affiliations": [
        "Menzies Research Institute Tasmania, Hobart, Tasmania, Australia"
      ],
      "name": "Graeme Jones"
    },
    {
      "affiliations": [
        "Department of Sports Medicine, University of Nottingham, Nottingham, UK",
        "Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK"
      ],
      "name": "Stefan Kluzek"
    },
    {
      "affiliations": [
        "Division of Rheumatology, Allergy and Clinical Immunology, Department of Medicine, University of California, Davis, California, USA"
      ],
      "name": "Nancy E Lane"
    },
    {
      "affiliations": [
        "University of Manchester—The Victoria University of Manchester Campus, Manchester, UK"
      ],
      "name": "Claudia Lindner"
    },
    {
      "affiliations": [
        "Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA"
      ],
      "name": "John A Lynch"
    },
    {
      "affiliations": [
        "Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"
      ],
      "name": "Joyce van Meurs"
    },
    {
      "affiliations": [
        "La Trobe Sport and Exercise Medicine Research Centre, La Trobe University—Bundoora Campus, Melbourne, Victoria, Australia",
        "Australian IOC Research Centre, Melbourne, Victoria, Australia"
      ],
      "name": "Andrea Britt Mosler"
    },
    {
      "affiliations": [
        "Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA",
        "University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA"
      ],
      "name": "Amanda E Nelson"
    },
    {
      "affiliations": [
        "University of California San Francisco, San Francisco, California, USA"
      ],
      "name": "Michael C Nevitt"
    },
    {
      "affiliations": [
        "Erasmus Universiteit Rotterdam, Rotterdam, The Netherlands"
      ],
      "name": "Edwin H G Oei"
    },
    {
      "affiliations": [
        "Department of General Practice, Erasmus University Medical Centre, Rotterdam, The Netherlands"
      ],
      "name": "Jos Runhaar"
    },
    {
      "affiliations": [
        "Orthopedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"
      ],
      "name": "Jinchi Tang"
    },
    {
      "affiliations": [
        "Department of Orthopaedics, Erasmus University Medical Center, Rotterdam, The Netherlands"
      ],
      "name": "Harrie Weinans"
    },
    {
      "affiliations": [
        "Orthopedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, Zuid-Holland, The Netherlands"
      ],
      "name": "Rintje Agricola"
    }
  ],
  "title": "Severe pincer morphology is associated with incident hip osteoarthritis: prospective individual participant data from 18 935 hips from the World COACH consortium",
  "uid": "6ef5bf73-1a81-51a1-8f4b-7654504e7f5c"
}