{
  "abstract": "Purpose The cross-sectional and longitudinal associations between accelerated biological ageing and the risk of cataract and other blinding eye diseases (including glaucoma and age-related macular degeneration (AMD)) remain unclear.Methods We included participants aged 40 and above with biological ages, including phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge) and retinal age (RetiAge), from the US National Health and Nutrition Examination Survey (NHANES) and UK Biobank. The cross-sectional analyses were conducted to identify associations of PhenoAge or KDMAge acceleration with cataract and other blinding eye diseases using logistic regression. In a prospective UK cohort, we explored the relationships between the acceleration of PhenoAge, KDMAge or RetiAge and cataract and other blinding eye diseases using the Cox proportional hazards model.Results This study consisted of 5433 participants from the US NHANES and 269 615 participants from the UK Biobank. In both cross-sectional and longitudinal analyses, accelerated biological ageing was positively associated with an increased risk of cataract (all p<0.05). In a longitudinal cohort, RetiAge acceleration demonstrated the larger effect size estimates (HR 1.54 (95% CI 1.38 to 1.73)) compared with PhenoAge acceleration (HR 1.05 (95% CI 1.03 to 1.08)) and KDMAge acceleration (HR 1.06 (95% CI 1.04 to 1.08)). Only in the UK population, risks of glaucoma showed stronger links with KDMAge acceleration (HR 1.06 (95% CI 1.01 to 1.11)), while AMD showed more pronounced associations with PhenoAge acceleration (HR 1.08 (95% CI 1.02 to 1.14)).Conclusions Accelerated biological ageing might represent a potential target of assessment and intervention for cataract.",
  "authors": [
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Kaiyi Chi"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Yiru He"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Xin Zuo"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Chunran Lai"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Jiahui Cao"
    },
    {
      "affiliations": [
        "Guangzhou Medical University, Guangzhou, China"
      ],
      "name": "Yican Ying"
    },
    {
      "affiliations": [
        "Guangzhou Medical University, Guangzhou, China"
      ],
      "name": "Binghua Zhang"
    },
    {
      "affiliations": [
        "Guangzhou Medical University, Guangzhou, China"
      ],
      "name": "Renyu Li"
    },
    {
      "affiliations": [
        "Guangzhou Medical University, Guangzhou, China"
      ],
      "name": "Meilin Chen"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Xiaolu Tan"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Qinyi Li"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Shan Wang"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Qiaowei Wu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Jiayue He"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Lei Liu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China"
      ],
      "name": "Yijun Hu"
    },
    {
      "affiliations": [
        "Ophthalmology, Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia",
        "Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia"
      ],
      "name": "Zhuoting Zhu"
    },
    {
      "affiliations": [
        "Singapore Eye Research Institute, Singapore National Eye Centre, Singapore"
      ],
      "name": "Xiayin Zhang"
    },
    {
      "affiliations": [
        "Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, China",
        "Fifth Clinical Institute of Shantou University Medical College, Shantou, China"
      ],
      "name": "Honghua Yu"
    }
  ],
  "title": "Linking accelerated biological ageing to cataract susceptibility: evidence from cross-cohort analysis",
  "uid": "df21223d-9a28-56e7-bae8-86f76c688782"
}