{
  "abstract": "Background/Aims To identify sociodemographic and clinical factors associated with best-corrected visual acuity (BCVA) restoration at the visit after lost to follow-up (LTFU) in patients with myopic choroidal neovascularization (mCNV) treated with antivascular endothelial growth factor intravitreal injections (IVI).Methods A multicentre, retrospective cohort study was conducted in China of mCNV patients receiving injections who were LTFU >6 months. Data were collected from baseline visit, pre-LTFU, initial post-LTFU visit and 6 months post-LTFU, and the final visit. Logistic regression analyses assessed associations between sociodemographic/clinical factors and BCVA restoration.Results The study included 1155 LTFU patients with mCNV (mean (SD) age: 54 (16) years; 61.6% female), with 66.6% achieving BCVA restoration at the initial post-LTFU visit after LTFU (mean(SD) duration: 315 (154) days. Patients with BCVA restoration were younger (p=0.004), more often from eastern China (p=0.022), and had shorter LTFU duration (p=0.013). Stratification by pre-LTFU BCVA showed that patients with BCVA ≥20/40 had lower restoration odds (OR 0.65, 95% CI 0.44 to 0.96; p=0.032) compared with those with BCVA <20/200. BCVA decline was associated with increased central subfield thickness(CST) (OR 1.52, 95% CI 1.15 to 2.01; p=0.004). Among 223 patients with ≥6 months post-LTFU, those with initial post-LTFU CST >280 µm had higher BCVA restoration odds (OR 1.98, 95% CI 1.02 to 3.92; p=0.046).Conclusions Better pre-LTFU BCVA (≥20/40) increased post-LTFU deterioration risk (associated with progressive CST thickening), while elevated post-LTFU CST (>280 µm) predicted higher BCVA restoration odds in patients with sustained follow-up, supporting CST-guided monitoring and early intervention for high-risk groups.",
  "authors": [
    {
      "affiliations": [
        "Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
        "National Clinical Research Center for Eye Diseases",
        "Shanghai Key Laboratory of Ocular Fundus Diseases",
        "Shanghai Engineering Center for Visual Science and Photomedicine",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases",
        "Shanghai Clinical Research Center for Eye Diseases",
        "Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"
      ],
      "name": "Yupeng Xu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
        "National Clinical Research Center for Eye Diseases",
        "Shanghai Key Laboratory of Ocular Fundus Diseases",
        "Shanghai Engineering Center for Visual Science and Photomedicine",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases",
        "Shanghai Clinical Research Center for Eye Diseases",
        "Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"
      ],
      "name": "Yinchen Shen"
    },
    {
      "affiliations": [
        "Department of Scientific Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
        "National Clinical Research Center for Eye Diseases, Shanghai, China, Shanghai, People's Republic of China"
      ],
      "name": "Shu Li"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
        "National Clinical Research Center for Eye Diseases",
        "Shanghai Key Laboratory of Ocular Fundus Diseases",
        "Shanghai Engineering Center for Visual Science and Photomedicine",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases",
        "Shanghai Clinical Research Center for Eye Diseases",
        "Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"
      ],
      "name": "Chuandi Zhou"
    },
    {
      "affiliations": [
        "Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, People's Republic of China"
      ],
      "name": "Xiaorong Li"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
        "National Clinical Research Center for Eye Diseases",
        "Shanghai Key Laboratory of Ocular Fundus Diseases",
        "Shanghai Engineering Center for Visual Science and Photomedicine",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases",
        "Shanghai Clinical Research Center for Eye Diseases",
        "Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"
      ],
      "name": "Xiaolu Yang"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, People's Republic of China"
      ],
      "name": "Xian Wang"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Calmette Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China"
      ],
      "name": "Yong Li"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China"
      ],
      "name": "Dawei Sun"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Second Hospital & Clinical Medical School, Lanzhou University",
        "Gansu Clinical Research Center for Eye Diseases, Lanzhou, Gansu, People's Republic of China"
      ],
      "name": "Wenfang Zhang"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou First People's Hospital, Xuzhou Eye Disease Prevention and Treatment Institute, Xuzhou, Jiangsu, People's Republic of China"
      ],
      "name": "Suyan Li"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China"
      ],
      "name": "Han Zhang"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China"
      ],
      "name": "Hongbin Lv"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People's Republic of China"
      ],
      "name": "Xiang Ma"
    },
    {
      "affiliations": [
        "Department of ophthalmology, Guangdong Eye Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, People's Republic of China"
      ],
      "name": "Honghua Yu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China"
      ],
      "name": "Zongming Song"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, People's Republic of China"
      ],
      "name": "Tianzi Zhang"
    },
    {
      "affiliations": [
        "Eye Hospital, the First Affiliated Hospital of Harbin Medical University",
        "Key laboratory of basic and clinical research of Heilongjiang Province, Harbin, Heilongjiang, People's Republic of China"
      ],
      "name": "Xuhui Yu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Southwest Hospital/Southwest Eye Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China"
      ],
      "name": "Yong Liu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, The Fourth People's Hospital of Shenyang, Shenyang Eye Research Institute, Key Laboratory of Ophthalmology of Liaoning, Shenyang, Liaoning, People's Republic of China"
      ],
      "name": "Tongtong Niu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, the Second Affiliated Hospital of Army Medical University, Chongqing, People's Republic of China"
      ],
      "name": "Rongdi Yuan"
    },
    {
      "affiliations": [
        "The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Jiangxi Province Key Laboratory of Ophthalmology and Vision Sciences, Jiangxi clinical research center for ophthalmic disease, Jiangxi Provincial Key Laboratory of Vitreoretinal Diseases for Health, Nanchang, Jiangxi, People's Republic of China"
      ],
      "name": "Zhipeng You"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, TongRen Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China"
      ],
      "name": "Qing Liu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, General Hospital of Central Theater Command, Wuhan, Hubei, People's Republic of China"
      ],
      "name": "Yanping Song"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
        "National Clinical Research Center for Eye Diseases",
        "Shanghai Key Laboratory of Ocular Fundus Diseases",
        "Shanghai Engineering Center for Visual Science and Photomedicine",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases",
        "Shanghai Clinical Research Center for Eye Diseases",
        "Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"
      ],
      "name": "Xiaodong Sun"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
        "National Clinical Research Center for Eye Diseases",
        "Shanghai Key Laboratory of Ocular Fundus Diseases",
        "Shanghai Engineering Center for Visual Science and Photomedicine",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases",
        "Shanghai Clinical Research Center for Eye Diseases",
        "Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"
      ],
      "name": "Zhi Zheng"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
        "National Clinical Research Center for Eye Diseases",
        "Shanghai Key Laboratory of Ocular Fundus Diseases",
        "Shanghai Engineering Center for Visual Science and Photomedicine",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases",
        "Shanghai Clinical Research Center for Eye Diseases",
        "Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"
      ],
      "name": "Xun Xu"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine",
        "National Clinical Research Center for Eye Diseases",
        "Shanghai Key Laboratory of Ocular Fundus Diseases",
        "Shanghai Engineering Center for Visual Science and Photomedicine",
        "Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases",
        "Shanghai Clinical Research Center for Eye Diseases",
        "Shanghai Key Clinical Specialty, Shanghai, People's Republic of China"
      ],
      "name": "Kun Liu"
    }
  ],
  "title": "Clinical characteristics and visual recovery in lost-to-follow-up myopic choroidal neovascularization treated with antivascular endothelial growth factor therapy",
  "uid": "63550c5f-d470-5fb1-8517-2f96bf2d11d7"
}