{
  "abstract": "Aims To determine baseline risk factors of incident open-angle glaucoma (OAG) in an elderly white population.Methods Prospective-longitudinal population-based study. 12 years following baseline examinations, subjects were re-invited for follow-up examinations using the same methodology undertaken at baseline. 1092 (74%) were re-examined. In multivariable logistic regression analysis, factors with a p value of ≤0.2 in univariate analysis were included in the model.Results Overall, 826 subjects met final inclusion criteria. In multivariable regression analysis adjusted for potential confounders, baseline factors associated with incident glaucoma were: pseudoexfoliation (PEX) (p=0.002); higher intraocular pressure (IOP) (p<0.001); cup-to-disc ratio (p=0.020); family history of glaucoma (p=0.029); history of heart attack (p=0.002), blood pressure (BP) ≤140/90 without anti-hypertensive treatment (p=0.019) compared with BP >140/90. Increased hours of sleep (p=0.043) and alcohol consumption (p=0.030) were found to be protective factors.Conclusion Increased IOP, PEX, increased vertical c/d ratio, family history of glaucoma, history of heart attack and BP ≤140/90 increased the risk for incident OAG. Increased hours of sleep and alcohol consumption were inversely associated with the development of incident glaucoma.",
  "authors": [
    {
      "affiliations": [
        "1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Panagiota Ntonti"
    },
    {
      "affiliations": [
        "UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA"
      ],
      "name": "Anne L Coleman"
    },
    {
      "affiliations": [
        "Wayne State University, Detroit, Michigan, USA"
      ],
      "name": "Masao Roy Wilson"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA"
      ],
      "name": "Alon Harris"
    },
    {
      "affiliations": [
        "1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Evangelia Papakonstantinou"
    },
    {
      "affiliations": [
        "1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Dimitrios A Giannoulis"
    },
    {
      "affiliations": [
        "Laboratory of Research and Clinical Applications in Opthalmology (LARCAO), Department of Opthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Vassilis Kilintzis"
    },
    {
      "affiliations": [
        "Department of Hygiene and Epidemiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Anna-Bettina Haidich"
    },
    {
      "affiliations": [
        "UCLA Stein Eye Institute, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA"
      ],
      "name": "Fei Yu"
    },
    {
      "affiliations": [
        "1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Theofanis Pappas"
    },
    {
      "affiliations": [
        "Laboratory of Research and Clinical Applications in Opthalmology (LARCAO), Department of Opthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Eleftherios Anastasopoulos"
    },
    {
      "affiliations": [
        "1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Iordanis Vagiakis"
    },
    {
      "affiliations": [
        "1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece",
        "Laboratory of Research and Clinical Applications in Opthalmology (LARCAO), Department of Opthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Anastasia Raptou"
    },
    {
      "affiliations": [
        "1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece",
        "Laboratory of Research and Clinical Applications in Opthalmology (LARCAO), Department of Opthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Grigoria Tzoanou"
    },
    {
      "affiliations": [
        "1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece",
        "Laboratory of Research and Clinical Applications in Opthalmology (LARCAO), Department of Opthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"
      ],
      "name": "Fotis Topouzis"
    }
  ],
  "title": "Baseline risk factors for the development of open-angle glaucoma in a 12-year glaucoma incidence study: the Thessaloniki Eye Study",
  "uid": "5c43bad2-2359-5c31-9127-9d968b791a14"
}