{
  "abstract": "Aims To quantify the regional ischaemic index (ISI) in eyes with retinal vein occlusion (RVO) and to determine its correlation with macular oedema (ME).Methods In this retrospective study, ultra-widefield fluorescein angiography was performed in 46 eyes with RVO. The retinal ISI was calculated for the perimacular area (PMA), near-peripheral area (NPA), mid-peripheral area (MPA), and far-peripheral area (FPA), each further divided into superior-inferior and nasal-temporal segments. Central macular thickness (CMT) was measured with spectral-domain optical coherence tomography. Associations between regional ISI and CMT were analysed using Spearman’s correlation and linear regression.Results 46 eyes of 46 RVO patients were enrolled. Mean CMT was 453.73±301.48 µm. ISI in the S-NPA (superior NPA) strongly correlated with that in the I-NPA (inferior NPA) (r=0.53, p<0.001); a moderate correlation was observed between S-MPA (superior MPA) and I-MPA (inferior MPA) (r=0.32, p=0.03). Linear regression showed that S-NPA ISI predicted I-NPA ISI (B=0.54, p<0.001) and S-MPA ISI predicted I-MPA ISI (B=0.42, p=0.004). Among regions, PMA (r=0.31, p=0.04), I-NPA (r=0.35, p=0.02) and I-FPA (inferior FPA) (r=0.33, p=0.048) significantly correlated with CMT. Linear regression identified that PMA ISI (B=0.32, p=0.03) and I-NPA ISI (B=0.42, p=0.007) could independently predict increased CMT.Conclusions ME severity in RVO was correlated with PMA and I-NPA ischaemia. Moreover, these specific regional ISI values could independently predict CMT, highlighting potential targets for personalised therapy.",
  "authors": [
    {
      "affiliations": [
        "Shenzhen Eye Hospital, Jinan University, Shenzhen, Guangdong, China"
      ],
      "name": "Bingyu Bai"
    },
    {
      "affiliations": [
        "Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China"
      ],
      "name": "Dong Fang"
    },
    {
      "affiliations": [
        "Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China"
      ],
      "name": "Yijing Zhuang"
    },
    {
      "affiliations": [
        "Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China"
      ],
      "name": "Lujia Feng"
    },
    {
      "affiliations": [
        "Shenzhen Eye Hospital, Jinan University, Shenzhen, Guangdong, China",
        "Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, Guangdong, China"
      ],
      "name": "Shaochong Zhang"
    }
  ],
  "title": "Regional-specific retinal ischaemic index guided by ultra-widefield fluorescein angiography correlates with macular oedema in retinal vein occlusion",
  "uid": "13909aca-c217-58d2-b39f-278b2cceebd0"
}