{
  "abstract": "Background Intraocular pressure (IOP) exhibits significant fluctuations in response to changes in body posture. Postural modification may serve as a potential adjunctive strategy for IOP management in glaucoma patients.Methods A total of 144 patients with glaucoma were enrolled in this study. IOP was measured and compared between the high-pillow position (head elevated by 20–35° using two pillows) and the supine position. Additionally, changes in jugular venous lumen in response to postural variation were evaluated via ultrasonography in 20 healthy volunteers.Results Compared with the supine position, the high-pillow position was associated with significantly elevated IOP, increased 24-hour IOP fluctuation and reduced ocular perfusion pressure (OPP) (all p<0.001). Greater postural IOP fluctuation (ΔIOP) was observed in younger individuals (p=0.027) and patients with primary open-angle glaucoma (POAG) (p<0.001). Multiple regression analysis identified thicker central corneal thickness and the presence of POAG (vs normal-tension glaucoma) as positive predictors of larger ΔIOP changes (both p<0.05). Ultrasonography in healthy volunteers revealed significant constriction of both internal and external jugular venous lumen in the high-pillow position (all p<0.001), accompanied by an increase in maximum blood flow velocity of the internal jugular vein (p=0.013).Conclusion Compared with the supine position, the high-pillow position is associated with increased IOP and decreased OPP in patients with glaucoma, which may be linked to jugular venous compression. Patients with glaucoma may benefit from avoiding sleeping postures that induce jugular venous compression to mitigate postural IOP elevation, though further studies are needed to validate these preliminary associations.",
  "authors": [
    {
      "affiliations": [
        "Eye Center, Zhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, China. Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases. Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China",
        "Hangzhou Third People's Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"
      ],
      "name": "Tong Liu"
    },
    {
      "affiliations": [
        "Eye Center, Zhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, China. Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases. Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China"
      ],
      "name": "Mengyuan Hu"
    },
    {
      "affiliations": [
        "Eye Center, Zhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, China. Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases. Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China"
      ],
      "name": "Xin Liu"
    },
    {
      "affiliations": [
        "Huanjiang Laboratory, State Key Laboratory of Silicon and Advanced Semiconductor Materials, Zhejiang University School of Aeronautics and Astronautics, Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Hangzhou, China"
      ],
      "name": "Zongrong Wang"
    },
    {
      "affiliations": [
        "Eye Center, Zhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, China. Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases. Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China"
      ],
      "name": "Ke Yao"
    },
    {
      "affiliations": [
        "Eye Center, Zhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, China. Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases. Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China"
      ],
      "name": "Min Chen"
    },
    {
      "affiliations": [
        "Eye Center, Zhejiang University, Eye Center of Second Affiliated Hospital, School of Medicine, China. Zhejiang Provincial Key Laboratory of Ophthalmology. Zhejiang Provincial Clinical Research Center for Eye Diseases. Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, China"
      ],
      "name": "Kaijun Wang"
    }
  ],
  "title": "Association of high-pillow sleeping posture with intraocular pressure in patients with glaucoma",
  "uid": "fb59a51e-6381-5b1d-aff3-86f73adff866"
}