{
  "abstract": "Aim To investigate the effect of the Defocus Incorporated Soft Contact (DISC) lenses on myopia progression and choroidal thickness (ChT) of Chinese mainland children over a period of 12 months.Methods This was a prospective double-blind randomised controlled trial involving 84 myopic children. Subjects were randomly assigned to use of either DISC or single vision contact lens (SVL). Cycloplegic spherical equivalent refraction (SER), axial length (AL) and ChT were measured at 6 and 12 months.Results For 12 months, the average changes in SER and AL in the DISC group were (−0.50±0.41) D and (0.22±0.13) mm. Corresponding values in the SVL group were (−1.23±0.50) D and (0.49±0.15) mm. Myopia control efficacy in SER was 59% and 55% in AL. For those aged under 10, myopia control efficacy in SER is higher at 95% in 6 months and 71.4% in 12 months. ChT increased by 0.16±24.46 µm in the DISC group, while in contrast, it thinned in the SVL group (−9.11±32.25 µm) after 12 months. ChT changes demonstrated a significant negative association with AL over 12 months in the DISC group but not in the SVL group. In contrast, ChT change over 12 months was significantly negatively associated with initial ChT in the SVL group, but not in the DISC group.Conclusions DISC lenses effectively slowed myopia progression and AL compared with SVL, especially for younger children. Myopia defocus treatment changes the original intrinsic relationship between ChT and myopia progression, providing strong evidence that myopia defocus design controls myopia progression by changing ChT.",
  "authors": [
    {
      "affiliations": [
        "Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"
      ],
      "name": "Lin Liu"
    },
    {
      "affiliations": [
        "Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"
      ],
      "name": "Jinghui Wang"
    },
    {
      "affiliations": [
        "School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"
      ],
      "name": "Dennis Yan-Yin Tse"
    },
    {
      "affiliations": [
        "School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"
      ],
      "name": "Bing Zuo"
    },
    {
      "affiliations": [
        "Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"
      ],
      "name": "Desheng Song"
    },
    {
      "affiliations": [
        "Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"
      ],
      "name": "Bei Du"
    },
    {
      "affiliations": [
        "Ophthalmology and Visual Science, Eye & ENT Hospital of Fudan University, Shanghai, China"
      ],
      "name": "Zhi Chen"
    },
    {
      "affiliations": [
        "School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China",
        "Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China",
        "Centre for Eye and Vision Research (CEVR), Hong Kong, China"
      ],
      "name": "Chi Ho To"
    },
    {
      "affiliations": [
        "School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China",
        "Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China",
        "Centre for Eye and Vision Research (CEVR), Hong Kong, China"
      ],
      "name": "Rachel Ka Man Chun"
    },
    {
      "affiliations": [
        "National Clinical Research Center for Ocular Diseases, Wenzhou Medical University Eye Hospital, Wenzhou, Zhejiang, China"
      ],
      "name": "Jun Jiang"
    },
    {
      "affiliations": [
        "Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Centre for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China"
      ],
      "name": "Ruihua Wei"
    }
  ],
  "title": "Effect of daily disposable Defocus Incorporated Soft Contact lens on myopia control: a 1-year multicentre randomised controlled trial",
  "uid": "011d6d30-5c8c-5e0d-9947-04c9f3af021e"
}