{
  "abstract": "Aims To compare the efficacy in achieving and maintaining control of inflammation between adalimumab biosimilars and originator adalimumab as initial biologic treatment among patients with non-infectious uveitis (NIU).Methods This is a multicentre retrospective cohort study. Events of uveitis relapse were noted per eye following initiation of adalimumab treatment. Relapses were defined as the clinical diagnosis of intraocular inflammation, requiring an increase or change in local or systemic immunosuppression. Relapse rates and time to first relapse by 12 months were compared between eyes treated with originator adalimumab or a biosimilar.Results 260 eyes of 148 patients diagnosed with NIU were treated with either originator adalimumab (n=193, 74.23%) or a biosimilar (n=67, 25.77%). Median follow-up from baseline for patients who did not relapse was 24.0 months (IQR 18.0, 24.0). Uveitis relapses occurred in 97 eyes (37.31%, 76 in the originator adalimumab group and 21 in the biosimilar group). By 12 months, the estimated relapse rate was 24.2% in the originator adalimumab group versus 28.3% in the biosimilar group (relative risk=1.17, 95% CI 0.58 to 1.77). The average time to relapse by 12 months follow-up for the originator adalimumab group was 4.91 months compared with 5.04 months in the biosimilar group (mean difference 0.13 months, 95% CI −1.33 to 1.54 months).Conclusion Our study suggests that by 12 months of use, biosimilar adalimumab agents were not inferior to originator adalimumab in preventing disease relapse among patients with refractory NIU. These results support the use of biosimilar adalimumab for treating NIU.",
  "authors": [
    {
      "affiliations": [
        "Department of Ophthalmology, Lady Davies Carmel Medical Center, Haifa, Israel",
        "Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel"
      ],
      "name": "Oren Tomkins-Netzer"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Auckland District Health Board, Auckland, New Zealand"
      ],
      "name": "Rachael L Niederer"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel",
        "Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"
      ],
      "name": "Radgonde Amer"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Lady Davies Carmel Medical Center, Haifa, Israel"
      ],
      "name": "Shaul Sar"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Meir Medical Center, Kefar Sava, Israel"
      ],
      "name": "Raz Gepstein"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel",
        "Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv-Yafo, Israel"
      ],
      "name": "Zohar Habot-Wilner"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Emek Medical Center, Afula, Israel"
      ],
      "name": "Hana Shyriaieva"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Lady Davies Carmel Medical Center, Haifa, Israel"
      ],
      "name": "Rima Diab"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Auckland District Health Board, Auckland, New Zealand"
      ],
      "name": "James Brodie"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel"
      ],
      "name": "Jamel Corredores"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Eliane Rozanes"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv-Yafo, Israel"
      ],
      "name": "Shai Cohen"
    },
    {
      "affiliations": [
        "Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel"
      ],
      "name": "Ofra Barnett-Griness"
    },
    {
      "affiliations": [
        "Institute of Ophthalmology, University College London, London, UK"
      ],
      "name": "Sue Lightman"
    },
    {
      "affiliations": [
        "Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv-Yafo, Israel",
        "Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Michal Kramer"
    },
    {
      "affiliations": [
        "Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv-Yafo, Israel",
        "Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Israel"
      ],
      "name": "Yael Sharon"
    }
  ],
  "title": "Adalimumab biosimilars have similar efficacy to originator adalimumab when treating non-infectious uveitis",
  "uid": "e2f26b10-a7ff-5674-a9ba-cce60b23bfda"
}