{
  "abstract": "Aims To investigate the relationship between retinal structure symmetry and metamorphopsia in idiopathic epiretinal membrane (ERM) patients.Methods 181 consecutive ERM patients were divided into four groups based on vertical/horizontal metamorphopsia (MV/MH) presence. Clinical data, including best-corrected visual acuity (BCVA), metamorphopsia scores and optical coherence tomography (OCT)-assessed macular structure, were analysed. The Asymmetry Index (ASI), defined as the thickness difference ratio between corresponding retinal layers, was introduced. Univariate and multivariate linear regression explored relationships among BCVA, metamorphopsia and OCT patterns. Receiver operating characteristic (ROC) curves evaluated the discriminatory ability of OCT parameters for metamorphopsia.Results Vertical ASI (ASI-V) of the Ganglion cell layer and Inner plexiform layer complex (GCL+IPL) layer was significantly higher in MH groups (p<0.0001), while Horizontal ASI (ASI-H) was elevated in MV groups (p=0.0001). Strong correlations were found between MH and ASI-V (p<0.0001, R 2=0.4536), and MV and ASI-H (p<0.0001, R2=0.4870). Multivariate analysis showed a positive association between average metamorphopsia scores and ASI-T of the GCL+IPL layer (standardised beta=0.633, p<0.001). ROC analysis demonstrated good diagnostic accuracy of ASI-V for MH (area under the curve=0.823, Youden’s Index=0.669).Conclusions Vertical and horizontal asymmetric thickening of the GCL+IPL layer correlates with respective metamorphopsia types. The ASI of the GCL+IPL shows diagnostic superiority for metamorphopsia and may serve as a novel biomarker. These findings suggest that asymmetric thickening of the GCL+IPL layer, rather than overall thickening per se, may serve as the pathological basis for the development of metamorphopsia in ERM patients.",
  "authors": [
    {
      "affiliations": [
        "Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Wenjia Yan"
    },
    {
      "affiliations": [
        "Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Yuntong Li"
    },
    {
      "affiliations": [
        "Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Yanqiao Huang"
    },
    {
      "affiliations": [
        "Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Qiong Wang"
    },
    {
      "affiliations": [
        "Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Shuya Ke"
    },
    {
      "affiliations": [
        "Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Miner Yuan"
    },
    {
      "affiliations": [
        "Zhongshan Ophthalmic Center State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, Guangdong, China"
      ],
      "name": "Xiaoyan Ding"
    }
  ],
  "title": "Asymmetric thickening of the ganglion cell layer and inner plexiform layer complex correlates with metamorphopsia in epiretinal membrane patients",
  "uid": "3142d278-29fc-58ce-9321-e64bd2ef5a9d"
}