{
  "abstract": "The treatment of diabetic macular oedema (DMO) likely involves a series of treatment episodes separated by gaps during which no vascular endothelial growth factor inhibitor injections are delivered. Our aim is to differentiate the episodes and gaps with the isolation forests algorithm using the Fight Retinal Blindness! registry. We analysed 11 786 injection intervals (12 803 injections) and found that the period between adjacent injections≥38 weeks (95% CI 34 to 43 weeks) apart could be regarded as a treatment gap. The results will allow treatment episodes to be isolated so that the treatment patterns of DMO can be characterised more accurately.",
  "authors": [
    {
      "affiliations": [
        "Save Sight Institute, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Yohei Hashimoto"
    },
    {
      "affiliations": [
        "Save Sight Institute, The University of Sydney, Sydney, New South Wales, Australia",
        "Ophthalmology, Westmead Hospital, Westmead, New South Wales, Australia"
      ],
      "name": "Adrian Robert Hunt"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Hospital of the University of Coimbra, Coimbra, Portugal"
      ],
      "name": "Rufino Silva"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, OLVG Hospital, Amsterdam, The Netherlands"
      ],
      "name": "Antonella Witmer"
    },
    {
      "affiliations": [
        "Opthalmology, American University of Beirut Medical Center, Beirut, Lebanon"
      ],
      "name": "Wajiha Jurdi Kheir"
    },
    {
      "affiliations": [
        "Ophthalmology, Universita degli Studi di Milano, Milano, Italy"
      ],
      "name": "Francesco Viola"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, University Hospital of Basurto, Bilbao, Spain"
      ],
      "name": "Maite Arrazola"
    },
    {
      "affiliations": [
        "Ain Shams University, Cairo, Egypt"
      ],
      "name": "Mohamed Moghazy Mahgoub"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Medical University of Vienna, Vienna, Austria"
      ],
      "name": "Andreas Pollreisz"
    },
    {
      "affiliations": [
        "Eyes Wide Bay, Hervey Bay, Queensland, Australia"
      ],
      "name": "Zanne Harvey"
    },
    {
      "affiliations": [
        "Universitatsspital Zurich Augenklinik und Poliklinik, Zurich, Switzerland"
      ],
      "name": "Daniel Barthelmes"
    },
    {
      "affiliations": [
        "Save Sight Institute, The University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Mark C Gillies"
    }
  ],
  "title": "Differentiating treatment episodes from gaps in eyes with diabetic macular oedema",
  "uid": "615725b1-cead-53e9-8152-427ff7e00c58"
}