{
  "abstract": "To describe tocilizumab (TCZ) effectiveness in 15 children with refractory non-infectious uveitis. Reported outcomes are the number of relapses before and after treatment, steroid-sparing effect and drug retention rate. Macular oedema, fluorangiographic findings and ocular complications are also reported.The mean number of ocular relapses significantly decreased from 314 per 100 eyes/year to 106 per 100 eyes/year (p=0.016). A significant steroid-sparing effect was detected (p=0.037). TCZ drug survival was 77.4% at 6 months, followed by 61.9% at 12, 24 and 36 months of follow-up. Macular oedema and retinal vasculitis resolved in all affected eyes.",
  "authors": [
    {
      "affiliations": [
        "Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy"
      ],
      "name": "Jurgen Sota"
    },
    {
      "affiliations": [
        "Pediatric Rheumatology Unit, G d’Annunzio University, Chieti, Italy"
      ],
      "name": "Luciana Breda"
    },
    {
      "affiliations": [
        "Department of Sense Organs, Eye Clinic, Uveitis Unit, University La Sapienza, Rome, Italy"
      ],
      "name": "Maria Pia Paroli"
    },
    {
      "affiliations": [
        "Department of Rheumatology, Tripoli Children Hospital, Tripoli, Libya",
        "Department of Rheumatology Department, University of Tripoli, Tripoli, Libya"
      ],
      "name": "Soad Hashad"
    },
    {
      "affiliations": [
        "Neurovitae Center for Neuroscience, Institute of Translational Medicine, Neuroscience Research Group (NEUROS), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia"
      ],
      "name": "Alejandra de-la-Torre"
    },
    {
      "affiliations": [
        "DiBrain Department, University of Bari, Bari, Italy"
      ],
      "name": "Silvana Guerriero"
    },
    {
      "affiliations": [
        "Department of Internal Medicine, Division of Rheumatology, Gazi University Hospital, Ankara, Turkey"
      ],
      "name": "Abdurrahman Tufan"
    },
    {
      "affiliations": [
        "Neurovitae Center for Neuroscience, Institute of Translational Medicine, Neuroscience Research Group (NEUROS), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia"
      ],
      "name": "Juanita Cardona-López"
    },
    {
      "affiliations": [
        "Neurovitae Center for Neuroscience, Institute of Translational Medicine, Neuroscience Research Group (NEUROS), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia"
      ],
      "name": "María José Altamar-García"
    },
    {
      "affiliations": [
        "Pediatric Rheumatology Unit, G d’Annunzio University, Chieti, Italy"
      ],
      "name": "Saverio La Bella"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy"
      ],
      "name": "Antonio Vitale"
    },
    {
      "affiliations": [
        "Department of Experimental and Clinical Medicine, Internal Interdisciplinary Medicine Unit, Lupus Clinic, Careggi University Hospital, Florence, Italy"
      ],
      "name": "Edoardo Biancalana"
    },
    {
      "affiliations": [
        "Department of Maternal Infantile and Urological Sciences, Pediatric and Neonatology Unit, Università degli Studi di Roma La Sapienza, Rome, Italy"
      ],
      "name": "Emanuela Del Giudice"
    },
    {
      "affiliations": [
        "Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy"
      ],
      "name": "Francesca Minoia"
    },
    {
      "affiliations": [
        "Deparment of Pediatrics, King Faisal Specialist Hospital and Research Center, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia"
      ],
      "name": "Sulaiman Al-Mayouf"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy"
      ],
      "name": "Bruno Frediani"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy"
      ],
      "name": "Luca Cantarini"
    },
    {
      "affiliations": [
        "Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, Italy"
      ],
      "name": "Claudia Fabiani"
    }
  ],
  "title": "Tocilizumab effectiveness in paediatric non-infectious uveitis: data from the International AIDA Network Registries on ocular inflammatory disorders",
  "uid": "69999da0-65cd-573a-9de7-1beb97323943"
}