{
  "abstract": "Background Persistent full-thickness macular holes (FTMHs) following primary surgery represent a therapeutic challenge. Various surgical treatment approaches have been proposed. This study evaluates anatomical and functional outcomes of a temporary silicone oil tamponade in persistent FTMH in a larger cohort.Methods In a retrospective multicentre study, we included consecutive patients with persistent FTMH following vitrectomy with inner limiting membrane peeling and gas tamponade who were treated by a temporary silicone oil tamponade. FTMH morphology in optical coherence tomography, minimum linear diameter (MLD), closure rate and best-corrected visual acuity (BCVA) change were assessed.Results A total of 102 eyes of 102 consecutive patients were included. Median duration of silicone oil tamponade was 16.6 weeks (interquartile range (IQR) 12.0–22.1). Closure of the macular hole (flat/closed configuration) was achieved in 92.2% of eyes. Median BCVA improved significantly from 1.00 logMAR (IQR 0.70–1.15) to 0.70 logMAR (IQR 0.49–1.00; p<0.0001). Mean preoperative MLD was 460.7 µm (±194.2; range 136–1016), with significantly higher MLD in eyes with unsuccessful (614.4 µm±250.4) compared with successful (446.9 µm±183.9; p=0.019) silicone oil treatment.Conclusion Treatment of persistent FTMH with a temporary conventional silicone oil tamponade without retinal manipulation or postoperative positioning results in a high anatomical success rate and significant mean BCVA improvement. Success rate decreases with higher FTMH size.",
  "authors": [
    {
      "affiliations": [
        "Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany",
        "Department of Ophthalmology, University Medical Center Rostock, Rostock, Germany",
        "Department of Ophthalmology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany"
      ],
      "name": "Verena Schöneberger"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, University of Göttingen, Göttingen, Germany"
      ],
      "name": "Thea Hofmann"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"
      ],
      "name": "Jeany Q Lammert"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"
      ],
      "name": "Leonie Menghesha"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, University of Bonn, Bonn, Germany"
      ],
      "name": "Frank G Holz"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland"
      ],
      "name": "Nicolas Feltgen"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, University Medical Center Rostock, Rostock, Germany"
      ],
      "name": "Friederike Schaub"
    },
    {
      "affiliations": [
        "Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"
      ],
      "name": "Tim U Krohne"
    }
  ],
  "title": "Temporary silicone oil tamponade for persistent macular holes: a multicentre study",
  "uid": "e581b6a0-4fbe-5fe4-b1e8-1a5d92b11707"
}