{
  "abstract": "Aims Previous studies have suggested an association between retinal artery occlusion (RAO) and ischaemic stroke (IS), both associated with elevated inflammatory factors. However, the role of high-sensitivity C-reactive protein (hs-CRP) in the sequential onset of these two diseases is still unclear. Based on this evidence, we evaluated the association of hs-CRP with RAO and IS.Methods We examined hs-CRP from both the large multicentre cohort study UK Biobank and Chinese Retinal Artery Occlusion study. Cox proportional hazard models were used to study the association of hs-CRP with incident RAO and IS during the long-term follow-up in the UK Biobank. Logistic regression analysis was employed to assess the cross-sectional relationship between hs-CRP with RAO and IS in the Chinese cohort. A restricted cubic spline (RCS) approach was employed to evaluate potential non-linear associations of hs-CRP with IS.Results After exclusions, the analysis included 459 188 participants from the UK and 338 participants from China. Over a median follow-up of 12.2 years, 136 cases of incident RAO and 3206 cases of incident IS events were recorded in the UK Biobank. After multivariable adjustment, higher hs-CRP (per 10 mg/L) level was associated with increased risks of RAO (HR: 1.34, 95% CI: 1.01 to 1.76) and IS (HR: 1.24, 95% CI: 1.17 to 1.33). RCS analysis revealed a significant non-linear relationship between hs-CRP levels and incident IS (P non-linear<0.001). Furthermore, RAO patients with higher hs-CRP levels were more likely to be combined with IS (2.81 mg/L vs 10.14 mg/L, p<0.001). In the Chinese cohort, the association between hs-CRP with RAO and IS was further confirmed. Higher hs-CRP (per 1 mg/L) level was associated with increased risks of RAO (OR: 1.43, 95% CI: 1.15 to 1.78) and IS (OR: 1.13, 95% CI: 1.03 to 1.24).Conclusions Our findings underscore hs-CRP as a robust risk factor for both RAO and IS. Controlling hs-CRP levels might reduce the incidence of RAO and secondary stroke.",
  "authors": [
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China",
        "Department of Ophthalmology, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China"
      ],
      "name": "Yaxin Wang"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"
      ],
      "name": "Xiayin Zhang"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"
      ],
      "name": "Anyi Liang"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"
      ],
      "name": "Yongyi Niu"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"
      ],
      "name": "Daiyu Chen"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"
      ],
      "name": "Zijing Du"
    },
    {
      "affiliations": [
        "Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"
      ],
      "name": "Wei Wu"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"
      ],
      "name": "Feng Zhang"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"
      ],
      "name": "Guanrong Wu"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"
      ],
      "name": "Ying Fang"
    },
    {
      "affiliations": [
        "School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China"
      ],
      "name": "Xianwen Shang"
    },
    {
      "affiliations": [
        "Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC, Australia"
      ],
      "name": "Zhuoting Zhu"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"
      ],
      "name": "Yijun Hu"
    },
    {
      "affiliations": [
        "Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"
      ],
      "name": "Xiangjun Chen"
    },
    {
      "affiliations": [
        "Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China",
        "Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangzhou, China"
      ],
      "name": "Honghua Yu"
    },
    {
      "affiliations": [
        "Department of Nephrology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China"
      ],
      "name": "Lidan Hu"
    }
  ],
  "title": "High-sensitivity C-reactive protein and risk of retinal artery occlusion and ischaemic stroke: a cross-cohort study",
  "uid": "fdf72fa8-fc01-53bd-b902-076d7c97aea8"
}