{
  "abstract": "Aim To evaluate and compare the efficacy of combination treatment using 0.025% atropine and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses to 0.025% atropine and single vision (SV) spectacle lenses in slowing myopia progression in children with myopia.Methods Randomised controlled trial conducted on children aged 4–16 years with myopia between −1.00D and −6.00D and astigmatism ≤2.00D. Children were randomly allocated into two groups: 0.025% atropine and SV spectacle lenses treatment group (group A), and 0.025% atropine and DIMS spectacle lenses treatment group (group B). Cycloplegic spherical equivalent refraction (SER) and axial length were measured at baseline, 6 and 12 months.Results 102 patients completed the 12-month follow-up: n=49 in group A, mean age 9.50±2.78 years and n=53 in group B, mean age 9.90±2.47 years. At 12 months, the mean AL±SD change was 0.18±0.16 mm in group A and 0.07±0.16 mm in group B (mean difference: 0.11, 95% CI: 0.05 to 0.17; p≤0.001). Mean SER±SD progression at 12 months was −0.19±0.42D and −0.09±0.35D in groups A and B, respectively (p=0.13). 39.6% of children in group B had no axial elongation over 12 months compared with 12.2% of the children in group A (p=0.002).Conclusions Combination treatment with 0.025% atropine and DIMS spectacle lenses is more effective in controlling axial elongation than 0.025% atropine with SV lenses. Although not significant, SER differences between groups were lower in group B. These findings support a potential additive effect of the two treatments.",
  "authors": [
    {
      "affiliations": [
        "Opthalmology Service, Hospital Clínico Universitario San Carlos, Madrid, Spain",
        "Ophthalmology, The Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain"
      ],
      "name": "Noemi Guemes-Villahoz"
    },
    {
      "affiliations": [
        "Opthalmology Service, Hospital Clínico Universitario San Carlos, Madrid, Spain"
      ],
      "name": "Paula Talavero González"
    },
    {
      "affiliations": [
        "Ophthalmology, The Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain",
        "Optometry and Vision, Complutense University of Madrid, Madrid, Spain"
      ],
      "name": "Paloma Porras-Ángel"
    },
    {
      "affiliations": [
        "Optometry and Vision, Complutense University of Madrid, Madrid, Spain"
      ],
      "name": "Rafael Bella-Gala"
    },
    {
      "affiliations": [
        "Optometry and Vision, Complutense University of Madrid, Madrid, Spain"
      ],
      "name": "Alicia Ruiz-Pomeda"
    },
    {
      "affiliations": [
        "Optometry and Vision, Complutense University of Madrid, Madrid, Spain"
      ],
      "name": "Beatriz Martin-Garcia"
    },
    {
      "affiliations": [
        "Opthalmology Service, Hospital Clínico Universitario San Carlos, Madrid, Spain",
        "Ophthalmology, The Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain"
      ],
      "name": "Elena Hernandez-Garcia"
    },
    {
      "affiliations": [
        "Optometry and Vision, Complutense University of Madrid, Madrid, Spain"
      ],
      "name": "Nunila Gomez de Liaño"
    },
    {
      "affiliations": [
        "Department of Optometry and Visual Sciences, City St George’s, University of London, London, UK",
        "HOYA Vision Care, Amsterdam, Netherlands"
      ],
      "name": "Rakhee Shah"
    },
    {
      "affiliations": [
        "Ophthalmology, The Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain",
        "Ophthalmology, Hospital Clinico, Instituto de Investigaciones Ramon Castroviejo, Universidad Complutense, Madrid, Spain"
      ],
      "name": "Julian Garcia-Feijoo"
    },
    {
      "affiliations": [
        "Ophthalmology, The Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain",
        "Ophthalmology, Hospital Clinico, Instituto de Investigaciones Ramon Castroviejo, Universidad Complutense, Madrid, Spain"
      ],
      "name": "Rosario Gomez-de-Liaño"
    }
  ],
  "title": "Atropine and Spectacle lens Combination Treatment (ASPECT): 12-month results of a randomised controlled trial for myopia control using a combination of Defocus Incorporated Multiple Segments (DIMS) lenses and 0.025% atropine",
  "uid": "54f59cae-1d6b-51f7-a835-98b202b1bfba"
}