{
  "abstract": "Purpose To explore the factors and frequency of interruptions in intravitreal treatment for patients with neovascular age-related macular degeneration (AMD) and to evaluate the demographic and clinical factors linked to the reasons for discontinuation.Methods In this multicentre study, patients who began anti-vascular endothelial growth factor (VEGF) treatment between January 2019 and December 2021 for treatment-naïve neovascular exudative AMD were retrospectively analysed. The overall incidence of treatment discontinuation, along with the rates for each specific cause, was calculated. The probability of each cause of discontinuation over time from the start of treatment, as well as the risk factors associated with each case, was also determined.Results 655 individuals (28.5%) discontinued intravitreal anti-VEGF therapy. Among the five main categories of causes for discontinuation (patient’s decision against clinician’s advice, continuation of therapy at another clinic, clinical decision, systemic diseases or death), clinical decision emerged as the most common reason for interruption. The qualitative evaluation of the Kaplan–Meier curves suggests a higher frequency of the clinical decision as a cause of discontinuation within the initial 2 years of treatment. Worse visual acuity increased the risk of discontinuation due to clinical decisions. Younger patients were more likely to stop anti-VEGF therapy by choice. Better visual acuity and longer distance from the clinic increased the likelihood of patients continuing treatment elsewhere.Conclusions The discontinuation of anti-VEGF treatment is common among individuals with neovascular AMD. Causes of discontinuation include not only clinician decisions but also those related to the patient’s health and personal choices.",
  "authors": [
    {
      "affiliations": [
        "Department of Surgical Sciences, University of Turin, Torino, Italy",
        "Department of Ophthalmology, ”City of Health and Science” Hospital, Turin, Italy"
      ],
      "name": "Enrico Borrelli"
    },
    {
      "affiliations": [
        "Department of Surgical Sciences, University of Turin, Torino, Italy",
        "Department of Ophthalmology, ”City of Health and Science” Hospital, Turin, Italy"
      ],
      "name": "Claudio Foti"
    },
    {
      "affiliations": [
        "Department of Surgical Sciences, University of Turin, Torino, Italy",
        "Department of Ophthalmology, ”City of Health and Science” Hospital, Turin, Italy"
      ],
      "name": "Lorena Ulla"
    },
    {
      "affiliations": [
        "Department of Human Sciences and Promotion of the Quality of Life, San Raffaele, Rome, Italy",
        "Unit of Clinical and Molecular Epidemiology IRCCS San Raffaele Roma, Rome, Italy"
      ],
      "name": "Annamaria Porreca"
    },
    {
      "affiliations": [
        "Dept. of Ophthalmology, University Vita Salute Hospital San Raffaele, Milano, Italy"
      ],
      "name": "Ugo Introini"
    },
    {
      "affiliations": [
        "Department of Translational Biomedicine Neuroscience, University of Bari, Bari, Italy"
      ],
      "name": "Maria Oliva Grassi"
    },
    {
      "affiliations": [
        "Department of Translational Biomedicine Neuroscience, University of Bari, Bari, Italy"
      ],
      "name": "Pasquale Viggiano"
    },
    {
      "affiliations": [
        "Dept. of Ophthalmology, University Vita Salute Hospital San Raffaele, Milano, Italy"
      ],
      "name": "Mario Peronetti"
    },
    {
      "affiliations": [
        "Dept. of Ophthalmology, University Vita Salute Hospital San Raffaele, Milano, Italy"
      ],
      "name": "Rebecca Toscani"
    },
    {
      "affiliations": [
        "Department of Translational Biomedicine Neuroscience, University of Bari, Bari, Italy"
      ],
      "name": "Giacomo Boscia"
    },
    {
      "affiliations": [
        "Department of Translational Biomedicine Neuroscience, University of Bari, Bari, Italy"
      ],
      "name": "Alba Chiara Termite"
    },
    {
      "affiliations": [
        "Department of Surgical Sciences, University of Turin, Torino, Italy"
      ],
      "name": "Carlo Gennaro"
    },
    {
      "affiliations": [
        "Department of Surgical Sciences, University of Turin, Torino, Italy",
        "Department of Ophthalmology, ”City of Health and Science” Hospital, Turin, Italy"
      ],
      "name": "Paola Marolo"
    },
    {
      "affiliations": [
        "Department of Translational Biomedicine Neuroscience, University of Bari, Bari, Italy"
      ],
      "name": "Francesco Boscia"
    },
    {
      "affiliations": [
        "Dept. of Ophthalmology, University Vita Salute Hospital San Raffaele, Milano, Italy"
      ],
      "name": "Francesco Bandello"
    },
    {
      "affiliations": [
        "Department of Surgical Sciences, University of Turin, Torino, Italy",
        "Department of Ophthalmology, ”City of Health and Science” Hospital, Turin, Italy"
      ],
      "name": "Michele Reibaldi"
    }
  ],
  "title": "Incidence and reasons for discontinuation of anti-VEGF treatment in neovascular age-related macular degeneration",
  "uid": "9edf9f2d-3573-573f-baa2-d1d5663ee878"
}