{
  "abstract": "Background We aimed to provide, through the Uveitis in Childhood National Cohort Study, population-based evidence on incidence, distribution and disease characteristics for childhood onset non-infectious uveitis.Methods Eligible children and young people (<18 years) were those newly diagnosed with non-infectious uveitis between 1 March 2020 and 28 February 2023. Cases were identified and recruited through passive surveillance across a multicentre network. Descriptive analysis of demographic, socioeconomic and clinical characteristics at diagnosis is reported alongside incidence rates, relative rates by region and sociodemographic patterning.Results 468 cases were identified, providing a minimal national disease incidence of 1.89/100 000 (95% CI 1.72 to 2.07). Among the 255 children recruited, anterior uveitis was predominant (76.9%) and 65% of cases were bilateral. Peak incidence was at 11–15 years. Children resident in deprived areas and those from non-White ethnic backgrounds were over-represented (28% and 31% of the cohort). One in seven children (15%) had a diagnosis of juvenile idiopathic arthritis (JIA), and 5% had tubulointerstitial nephritis. Although bilaterally poor vision was uncommon (16.8%), 44.3% had lost some vision in at least one eye.Conclusions There is a need to reconsider how best to deliver paediatric rheumatological and eye care that meets the needs of young people, as well as young children, with uveitis. The predominance of non-JIA-related uveitis calls for a shift in focus. There appears to be socioeconomic drivers of disease risk, which are worthy of future exploration and which have implications on the delivery of care for this chronic and blinding disease.",
  "authors": [
    {
      "affiliations": [
        "Population Policy and Practice Research and Teaching Department, UCL GOS Institute of Child Health, London, UK",
        "Great Ormond Street Hospital for Children NHS Trust, London, UK"
      ],
      "name": "Ameenat Lola Solebo"
    },
    {
      "affiliations": [
        "UCL GOS Institute of Child Health, London, UK"
      ],
      "name": "Salomey Kellett"
    },
    {
      "affiliations": [
        "Ophthalmology, Royal Victoria Hospital, Belfast, UK"
      ],
      "name": "Eibhlin McLoone"
    },
    {
      "affiliations": [
        "Uveitis and Scleritis Service, Moorfields Eye Hospital NHS Foundation Trust, London, London, UK",
        "Rheumatology, Great Ormond Street Hospital for Children, London, UK"
      ],
      "name": "Harry Petrushkin"
    },
    {
      "affiliations": [
        "Paediatric Ophthalmology, Alder Hey Children's NHS Foundation Trust, Liverpool, Merseyside, UK"
      ],
      "name": "Jose Gonzalez-Martin"
    },
    {
      "affiliations": [
        "Manchester Royal Eye Hospital, Manchester University Hospitals NHS Trust, Manchester, UK"
      ],
      "name": "Jane Ashworth"
    },
    {
      "affiliations": [
        "Sheffield Children's Hospital NHS Foundation Trust, Sheffield, UK"
      ],
      "name": "Jessy Choi"
    },
    {
      "affiliations": [
        "Ophthalmology Department, Bradford Royal Infirmary, Bradford, West Yorkshire, UK"
      ],
      "name": "Rachel F Pilling"
    },
    {
      "affiliations": [
        "Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK"
      ],
      "name": "Kate Armon"
    },
    {
      "affiliations": [
        "Nottingham University Hospitals NHS Trust, Nottingham, UK"
      ],
      "name": "Kishore Warrier"
    },
    {
      "affiliations": [
        "Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK"
      ],
      "name": "Srilakshmi M Sharma"
    },
    {
      "affiliations": [
        "Population, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health Population Policy and Practice, London, UK"
      ],
      "name": "Jugnoo S Rahi"
    },
    {
      "affiliations": [],
      "name": "Members of the UNICORNS (Uveitis in Childhood National Cohort Study) Group"
    }
  ],
  "title": "Incidence, sociodemographic and presenting clinical features of childhood non-infectious uveitis: findings from the UK national inception cohort study",
  "uid": "24793912-9c87-5c4a-939d-505bc58ebd17"
}