{
  "abstract": "Objectives To compare the measurement properties of paediatric patient-reported outcome measures (P-PROMs) used in clinical trials and practice for common conditions.Design Data from the Australian Paediatric Multi-Instrument Comparison study were used, including children aged 5–18 years with autism spectrum disorder (ASD) (n=510), asthma (n=487), eating disorder(s) (n=216), epilepsy (n=298), recurrent abdominal pain (n=392), sleep problems (n=346), dental problems (n=490), type 1 diabetes (T1D) (n=67), enuresis (n=182) and no health conditions (reference group) (n=1259). The acceptability, response distribution (floor/ceiling effects), known-groups validity, test-retest reliability, responsiveness and convergent validity of the Paediatric Quality of Life Inventory (PedsQL), EuroQol Group’s Youth instruments with three and five response options (EQ-5D-Y-3L and EQ-5D-Y-5L), Child Health Utility 9D (CHU9D), Assessment of Quality of Life 6D (AQoL-6D), Health Utilities Index Mark 3 and Patient-Reported Outcomes Measurement Information System Paediatric Profile 25 (PROMIS-25) were assessed.Results PedsQL, EQ-5D-Y-3L, EQ-5D-Y-5L, CHU9D and PROMIS-25 were easy and quick to complete, indicating acceptability. Only the EQ-5D-Y-3L and EQ-5D-Y-5L demonstrated ceiling effect issues. All measures were able to differentiate between children with no health conditions and children with each condition (p<0.001, effect sizes between 0.47 and 3.5), indicating known-groups validity. Test-retest reliability varied by condition; however, the PedsQL and EQ-5D-Y-5L were the most reliable.Conclusions Certain P-PROMs may be preferred in different conditions, that is, ASD (PedsQL and EQ-5D-Y-5L), asthma (PedsQL), eating disorder(s) (PedsQL and CHU9D), epilepsy (PedsQL and CHU9D), recurrent abdominal pain (PedsQL, EQ-5D-Y-5L and CHU9D), sleep problems (PedsQL), dental problems (PedsQL), T1D (PedsQL and CHU9D) and enuresis (PedsQL). Notably, the PedsQL performed favourably in all conditions assessed. More evidence is required on the responsiveness of P-PROMs to changes in child health.Trial registration number ACTRN12621000657820.",
  "authors": [
    {
      "affiliations": [
        "Melbourne Health Economics, The University of Melbourne School of Population and Global Health, Melbourne, Victoria, Australia"
      ],
      "name": "Renee Jones"
    },
    {
      "affiliations": [
        "Melbourne Health Economics, The University of Melbourne School of Population and Global Health, Melbourne, Victoria, Australia"
      ],
      "name": "Nancy Devlin"
    },
    {
      "affiliations": [
        "Melbourne Health Economics, The University of Melbourne School of Population and Global Health, Melbourne, Victoria, Australia"
      ],
      "name": "Kim Dalziel"
    },
    {
      "affiliations": [
        "Melbourne Health Economics, The University of Melbourne School of Population and Global Health, Melbourne, Victoria, Australia"
      ],
      "name": "Rachel O’Loughlin"
    },
    {
      "affiliations": [
        "Centre for Health Economics Research and Evaluation, University of Technology Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Brendan Mulhern"
    },
    {
      "affiliations": [
        "Department of Endocrinology and Diabetes, The Royal Children’s Hospital, Melbourne, Victoria, Australia",
        "Health Services and Economics, Murdoch Children’s Research Institute, Parkville, Victoria, Australia"
      ],
      "name": "Mary White"
    },
    {
      "affiliations": [
        "Respiratory and Sleep Medicine, The Royal Children’s Hospital Melbourne, Parkville, Victoria, Australia",
        "Respiratory, Murdoch Childrens Research Institute, Parkville, Victoria, Australia"
      ],
      "name": "Shivanthan Shanthikumar"
    },
    {
      "affiliations": [
        "Health Services and Economics, Murdoch Children’s Research Institute, Parkville, Victoria, Australia",
        "Department of General Medicine, Royal Children’s Hospital Melbourne, Parkville, Victoria, Australia"
      ],
      "name": "Katherine Chen"
    },
    {
      "affiliations": [
        "Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia",
        "Department of Dentistry, Royal Children’s Hospital, Melbourne, Victoria, Australia"
      ],
      "name": "Mihiri Silva"
    },
    {
      "affiliations": [
        "Department of Nursing, The University of Melbourne, Melbourne, Victoria, Australia",
        "Austin Health, Heidelberg, Victoria, Australia"
      ],
      "name": "Elizabeth Walkley"
    },
    {
      "affiliations": [
        "Health Services and Economics, Murdoch Children’s Research Institute, Parkville, Victoria, Australia"
      ],
      "name": "Lee Constable"
    },
    {
      "affiliations": [
        "Health Services and Economics, Murdoch Children’s Research Institute, Parkville, Victoria, Australia",
        "Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia"
      ],
      "name": "Harriet Hiscock"
    }
  ],
  "title": "Comparative performance of common paediatric patient-reported outcome measures (P-PROMs) across health conditions",
  "uid": "8c945633-40cc-5053-8abb-09875aae86c5"
}