{
  "abstract": "Objectives To develop a working definition of successful transition from paediatric to adult epilepsy services, assess transition success, identify predictors and determine whether success is associated with improved seizure outcomes in early adulthood.Design Retrospective cohort study.Setting Paediatric and adult epilepsy services in London, UK.Participants Patients aged 20–24 with epilepsy in the paediatric service database (2009–2023) who transitioned to adult care.Demographics Date of birth, sex, ethnicity.Exposures Age at first documented paediatric epilepsy clinical appointment (this is not age of epilepsy onset) and number of epilepsy-related comorbidities at age 17.Transition measure Success was defined by four criteria: developmentally appropriate initiation, comprehensive preparation using National Institute for Health and Care Excellence guidance, attendance at joint paediatric/adult transition clinic and adult follow-up within 6 months of transition clinic.Main outcome measure Change in seizure frequency between ages 17 and 20.Results Of 59 eligible patients, 72.9% (43/59) achieved successful transition. Criteria were well-met: initiation (91.5%), preparation (91.5%), joint clinic (79.7%) and follow-up (88.1%). Successful transition increased the odds of seizure improvement/remaining seizure-free (adjusted OR 4.28, 95% CI 1.07 to 17.19) after adjusting for: age at first paediatric epilepsy clinical appointment, sex, ethnicity and comorbidities. Males had higher odds of seizure improvement/remaining seizure free than females (adjusted OR 4.29, 95% CI 1.26 to 14.67).No significant association was seen with ethnicity or age at first appointment.Conclusions A novel transition success tool was developed. Larger, multicentre studies are needed to validate this tool and confirm associations with long-term outcomes.",
  "authors": [
    {
      "affiliations": [
        "University College London, London, UK"
      ],
      "name": "Shivana Neeta Modi"
    },
    {
      "affiliations": [
        "Imperial College London Department of Primary Care and Public Health, London, UK",
        "University College London Great Ormond Street Institute of Child Health, London, UK"
      ],
      "name": "Emmanouil Bagkeris"
    },
    {
      "affiliations": [
        "University College London, London, UK"
      ],
      "name": "Catalina Suarez-Rivera"
    },
    {
      "affiliations": [
        "University College London Hospitals NHS Foundation Trust, London, UK"
      ],
      "name": "Maria-Christina Petropoulos"
    },
    {
      "affiliations": [
        "Imperial College London Department of Primary Care and Public Health, London, UK"
      ],
      "name": "Dougal Hargreaves"
    }
  ],
  "title": "Measuring transition success from paediatric to adult epilepsy services and its association with seizure outcomes: a UK retrospective cohort study",
  "uid": "bd09e756-b25e-53c0-a9e0-038b29d8f404"
}