{
  "abstract": "The prevalence of invasive bacterial infection in young febrile infants is estimated at 1%–4%, with the highest rates in those <21 days. 1 UK guidelines recommend screening all febrile neonates for bacterial infection and starting empiric broad-spectrum antibiotics while awaiting results,2–4 but not routine antiviral therapy. However, a recent UK/Ireland prospective surveillance study reported an increased incidence of neonatal herpes simplex virus (HSV) infection of 6.0 per 100 000 live births, with substantial associated morbidity and mortality.5",
  "authors": [
    {
      "affiliations": [
        "Medical Research Building, Brighton and Sussex Medical School, Brighton, England, UK",
        "Academic Paediatrics, Royal Alexandra Children’s Hospital, Brighton, England, UK"
      ],
      "name": "Annalie Shears"
    },
    {
      "affiliations": [
        "Southampton Children’s Hospital, Southampton, England, UK"
      ],
      "name": "Georgina Yan"
    },
    {
      "affiliations": [
        "The London Research, Evaluation and Audit for Child Health (REACH) Network, London, UK"
      ],
      "name": "Rose Hartzenberg"
    },
    {
      "affiliations": [
        "The London Research, Evaluation and Audit for Child Health (REACH) Network, London, UK"
      ],
      "name": "George Lawson"
    },
    {
      "affiliations": [
        "The London Research, Evaluation and Audit for Child Health (REACH) Network, London, UK"
      ],
      "name": "Stephanie Habermann"
    },
    {
      "affiliations": [
        "Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast School of Medicine Dentistry and Biomedical Sciences, Belfast, UK",
        "Emergency Department, Royal‭ ‬Belfast‭ ‬Hospital‭ ‬for‭ ‬Sick‭ ‬Children, Belfast, UK"
      ],
      "name": "Thomas Waterfield"
    },
    {
      "affiliations": [
        "Paediatric Emergency Department, Imperial College Hospital NHS Healthcare Trust, London, UK"
      ],
      "name": "Ian K Maconochie"
    },
    {
      "affiliations": [
        "Paediatric Emergency Department, Imperial College Hospital NHS Healthcare Trust, London, UK",
        "Section of Paediatric Infectious Diseases, Imperial College London, London, UK"
      ],
      "name": "Ruud Gerard Nijman"
    },
    {
      "affiliations": [
        "Medical Research Building, Brighton and Sussex Medical School, Brighton, England, UK",
        "Academic Paediatrics, Royal Alexandra Children’s Hospital, Brighton, England, UK"
      ],
      "name": "Katy Fidler"
    },
    {
      "affiliations": [],
      "name": "FIRE was conducted by the REACH Collaborative"
    }
  ],
  "title": "Incidence of herpes simplex infection among febrile infants under 3 months of age: evidence from two multisite cohorts",
  "uid": "83796bff-37ce-5f92-baf7-f0c034377844"
}