{
  "abstract": "Objective To determine the prevalence of invasive bacterial infection (IBI) in a UK cohort of febrile infants aged 90 days and younger with positive urinalysis (PU) results.Design A planned secondary analysis of data from the Febrile Infant Diagnostic Assessment and Outcome study, a prospective multicentre observational cohort study.Setting 35 paediatric emergency departments and assessment units across the UK and Ireland, between 6 July 2022 and 31 August 2023.Patients Febrile infants aged 90 days and younger presenting to emergency care.Main outcome measures IBI rates, namely bacterial meningitis or bacteraemia, among febrile infants with PU results were compared with those with negative urinalysis (NU) results.Results 1480 of 1821 infants underwent urinalysis testing. 549 infants had PU results and 931 had NU results. 42/549 (7.7%) and 20/931 (2.2%) infants had IBI in the PU and NU groups, respectively. Of the IBI cases within the PU group, 5/549 (0.9%) were bacterial meningitis and 39/549 (7.1%) were bacteraemia, with two concomitant cases. Of the IBI cases in the NU group, there were 4/931 (0.4%) cases of bacterial meningitis and 18/931 (1.9%) cases of bacteraemia, with two concomitant cases. There were no bacterial meningitis cases in infants over 60 days of age or those with confirmed urinary tract infection (UTI).Conclusions The prevalence of bacteraemia was high (7.1%) among PU infants, while the prevalence of bacterial meningitis was low (0.9%), with PU or NU. These findings support existing data that older infants with suspected UTI are at low risk of bacterial meningitis.",
  "authors": [
    {
      "affiliations": [
        "Wellcome Wolfson Institute for Experimental Medicine, Queen’s University Belfast School of Medicine Dentistry and Biomedical Sciences, Belfast, UK"
      ],
      "name": "Holly Drummond"
    },
    {
      "affiliations": [
        "Wellcome Wolfson Institute for Experimental Medicine, Queen’s University Belfast School of Medicine Dentistry and Biomedical Sciences, Belfast, UK"
      ],
      "name": "Etimbuk Umana"
    },
    {
      "affiliations": [
        "Wellcome Wolfson Institute for Experimental Medicine, Queen’s University Belfast School of Medicine Dentistry and Biomedical Sciences, Belfast, UK"
      ],
      "name": "Clare Mills"
    },
    {
      "affiliations": [
        "Wellcome Wolfson Institute for Experimental Medicine, Queen’s University Belfast School of Medicine Dentistry and Biomedical Sciences, Belfast, UK",
        "Royal Belfast Hospital for Sick Children Emergency Department, Belfast, UK"
      ],
      "name": "Thomas Waterfield"
    }
  ],
  "title": "Prevalence of invasive bacterial infection among febrile infants with positive urinalysis results: a planned secondary analysis of the Febrile Infants Diagnostic assessment and Outcome (FIDO) prospective observational cohort study",
  "uid": "6c793a9e-c54e-5f1b-84f1-cfadd84d15ca"
}