{
  "abstract": "Background and objective Cardiorespiratory polygraphy (CRP) is the predominant technology used to diagnose obstructive sleep apnoea (OSA) in tertiary centres in the UK. Nocturnal pulse oximetry (NPO) is cheaper and more accessible. This study evaluates NPO indices’ ability to predict OSA in children with Down syndrome (DS).Methods Indices from simultaneous NPO and CRP recordings were compared in children with DS (aged 2–16 years) referred to evaluate OSA in two tertiary centres across an 8-year period. Receiver operating characteristic curves assessed the diagnostic accuracy of NPO indices, including ODI3 (3% Oxygen Desaturation Index) and ODI4 (4% Oxygen Desaturation Index). Two-by-two tables determined the sensitivities and specificities of cut-off values for predicting OSA.Results 387 children with DS were included with stand-alone NPO; 177 female (46.7%), median age 6.1 years (range 2.02–15.97). There were 265 children (68.5%) with Obstructive Apnoea–Hypopnoea Index (OAHI) ≥1/hour, 164 with OAHI ≥1<5/hour (42.4%), 51 with OAHI ≥5<10/hour (13.2%) and 50 with OAHI ≥10/hour (12.9%). ODI3 and ODI4 demonstrated the best predictive value for predicting OSA. An ODI3 ≥19/hour and an ODI4 ≥8/hour were associated with the highest combined sensitivity (59.2%/63.8%) and specificity (74.6%/71.3%), respectively.Conclusion Raised ODI3 and ODI4 predict moderate and severe OSA in children with DS with moderate specificity/sensitivity and have a low sensitivity for detecting mild OSA. The poor predictive performance of oximetry reflects the multifactorial nature of sleep disordered breathing in children with DS. We recommend oximetry is not used for diagnosis of OSA in DS and CRP/polysomnography should be used.",
  "authors": [
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children, Glasgow, UK"
      ],
      "name": "Hannah Vennard"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Southampton Children’s Hospital, Southampton, UK"
      ],
      "name": "Anna Selby"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children, Glasgow, UK"
      ],
      "name": "Menaga Ananthamoorthy"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children, Glasgow, UK"
      ],
      "name": "Elise Buchan"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children, Glasgow, UK"
      ],
      "name": "Paul Burns"
    },
    {
      "affiliations": [
        "University of Southampton Faculty of Medicine, Southampton, UK"
      ],
      "name": "Thomas L Wilkinson"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children, Glasgow, UK"
      ],
      "name": "Rebecca Lennon"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Southampton Children’s Hospital, Southampton, UK"
      ],
      "name": "Jonathan James"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children, Glasgow, UK"
      ],
      "name": "Neil Gibson"
    },
    {
      "affiliations": [
        "Mathematics & Statistics, University of Strathclyde, Glasgow, UK"
      ],
      "name": "David Young"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Great Ormond Street Hospital for Children, London, UK"
      ],
      "name": "Martin Samuels"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Southampton Children’s Hospital, Southampton, UK"
      ],
      "name": "Hazel J Evans"
    },
    {
      "affiliations": [
        "Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children, Glasgow, UK"
      ],
      "name": "Ross Langley"
    }
  ],
  "title": "Role of overnight oximetry in assessing the severity of obstructive sleep apnoea in children with Down syndrome: a dual-centre study",
  "uid": "2b4c82a0-a169-5d2d-a4fe-62aa6efa0d77"
}