{
  "abstract": "Background Teduglutide is a glucagon-like peptide 2 analogue with demonstrated efficacy in reducing parenteral solution (PS) requirements to facilitate enteral autonomy in children with short bowel syndrome-associated intestinal failure (SBS-IF). There is currently no clear consensus on how to wean PS and monitor children once treatment is commenced, with variable regimens utilised in published paediatric and adult studies. We aimed to develop a practical algorithm for PS weaning in children with SBS-IF responding to teduglutide for use in the real-world setting.Methods A modified Delphi approach was adopted to achieve consensus with input from a multidisciplinary group of paediatric clinicians with intestinal rehabilitation expertise.Results We describe the resulting PS-weaning algorithm, which is easy to use, pragmatic and paediatric focused.Conclusion Future studies will be required to validate the algorithm.",
  "authors": [
    {
      "affiliations": [
        "Department of Gastroenterology, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia",
        "Department of Paediatrics, University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Jessica A Eldredge"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia"
      ],
      "name": "Claudia Borg"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Women's and Children’s Hospital Adelaide, North Adelaide, South Australia, Australia",
        "Department of Paediatrics, The University of Adelaide, Adelaide, South Australia, Australia"
      ],
      "name": "Richard T L Couper"
    },
    {
      "affiliations": [
        "Department of Nutrition and Dietetics, Sydney Children’s Hospital Randwick, Randwick, New South Wales, Australia"
      ],
      "name": "Kate Dehlsen"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital, South Brisbane, Queensland, Australia"
      ],
      "name": "Looi C Ee"
    },
    {
      "affiliations": [
        "Department of Nutrition and Dietetics, Queensland Children’s Hospital, South Brisbane, Queensland, Australia"
      ],
      "name": "Julia Fox"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Monash Children’s Hospital, Clayton, Victoria, Australia",
        "Department of Paediatrics, Monash University, Melbourne, Victoria, Australia"
      ],
      "name": "Rupert Hinds"
    },
    {
      "affiliations": [
        "Department of Gastroenterology and Clinical Nutrition, Royal Children’s Hospital, Parkville, Victoria, Australia",
        "Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia"
      ],
      "name": "Kathleen McGrath"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, John Hunter Children’s Hospital, Newcastle, New South Wales, Australia",
        "Department of Paediatrics, The University of Newcastle, Newcastle, New South Wales, Australia"
      ],
      "name": "Scott Nightingale"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, The Children’s Hospital at Westmead, Westmead, New South Wales, Australia",
        "Department of Paediatrics, University of Sydney, Sydney, New South Wales, Australia"
      ],
      "name": "Juliana Puppi"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Sydney Children’s Hospital Randwick, Randwick, New South Wales, Australia"
      ],
      "name": "Michael Purcell"
    },
    {
      "affiliations": [
        "Department of Gastroenterology and Clinical Nutrition, Royal Children’s Hospital, Parkville, Victoria, Australia",
        "Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia"
      ],
      "name": "Jason Y K Yap"
    },
    {
      "affiliations": [
        "Department of Gastroenterology, Sydney Children’s Hospital Randwick, Randwick, New South Wales, Australia",
        "School of Women's and Children’s Health, University of New South Wales, Randwick, New South Wales, Australia"
      ],
      "name": "Chee Y Ooi"
    }
  ],
  "title": "Development of a consensus parenteral solution weaning algorithm for children with short-bowel syndrome associated intestinal failure responding to teduglutide therapy",
  "uid": "c718bc72-036e-53ab-b8a4-161c158c4125"
}